{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:24:39Z","timestamp":1764174279282,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Wroclaw Medical University","doi-asserted-by":"crossref","award":["730"],"award-info":[{"award-number":["730"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The CXCL12 [chemokine (C\u2013X\u2013C motif) ligand 12] is a member of the CXC family of chemokines and interacts with its CXCR4 receptor. The CXCL12\/CXCR4 axis is involved in regulation of proliferation, survival and trafficking of hematopoietic stem cells, including B lymphocytes and disruption within this signaling pathway has been implicated in pathogenesis of chronic lymphocytic leukemia (CLL). The aim of this study was to determine a potential association of the CXCL12 rs1801157 G &gt; A polymorphism with susceptibility to CLL, the disease course and efficacy of therapy. Also, expression of the CD74 and CD38 proteins on B cells was analyzed in relation to clinical parameters and genotyping results. A total of 124 patients with CLL and 75 healthy controls were studied. CXCL12 genotyping was performed using polymerase chain reaction \u2010 restriction fragment length polymorphism (PCR\u2010RFLP) method. The CD74 and CD38 surface expression was determined using flow cytometry. There was a significantly increased frequency of the <jats:italic>A<\/jats:italic> allele and <jats:italic>AA<\/jats:italic> genotype in CLL patients compared with control group (<jats:italic>P<\/jats:italic> &lt; 0.001 in both cases). In addition, the <jats:italic>A<\/jats:italic> allele was overrepresented among patients with worse response to therapy in comparison to other genotypes (<jats:italic>P<\/jats:italic> &lt; 0.001). On the contrary, patients carrying the <jats:italic>A<\/jats:italic> allele displayed lower grade of the disease at diagnosis more frequently than patients homozygous for the <jats:italic>G<\/jats:italic> allele (<jats:italic>P<\/jats:italic> = 0.037). Moreover, the <jats:italic>AA<\/jats:italic> homozygosity correlated with lower CD74 expression on B cells (<jats:italic>P<\/jats:italic> = 0.007). In conclusion, data from this study indicate that the CXCL12 rs1801157 G &gt; A polymorphism may affect CLL development, disease progression as well as response to treatment.<\/jats:p>","DOI":"10.1111\/tan.12810","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T07:02:42Z","timestamp":1463122962000},"page":"432-438","source":"Crossref","is-referenced-by-count":3,"title":["Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"87","author":[{"given":"A.","family":"Butrym","sequence":"first","affiliation":[{"name":"Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University  Wroclaw Poland"},{"name":"Department of Physiology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Gebura","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Iwaszko","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kuliczkowski","sequence":"additional","affiliation":[{"name":"Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bogunia\u2010Kubik","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences  Wroclaw Poland"},{"name":"Department of Internal, Occupational Diseases, Hypertension and Clinical Oncology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Internal, Occupational Diseases, Hypertension and Clinical Oncology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"448","article-title":"Advances in the diagnosis and treatment of chronic lymphocytic leukemia","volume":"2","author":"Abbott BL","year":"2004","journal-title":"Clin Adv Hematol 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