{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:13:39Z","timestamp":1766870019795},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["CU\u201057\u2010001\u2010HR"],"award-info":[{"award-number":["CU\u201057\u2010001\u2010HR"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>This study was a retrospective analysis of Thai patients undergoing T\u2010replete hematopoietic stem cell transplant from human leukocyte antigen (HLA<\/jats:styled-content>)\u2010identical sibling donors. We investigated 66 patients, including 40 patients with acute myeloid leukemia (AML<\/jats:styled-content>), 12 patients with acute lymphoblastic leukemia and 14 patients with chronic myeloid leukemia. Killer cell immunoglobulin\u2010like receptor (KIR<\/jats:styled-content>) genes and HLA<\/jats:styled-content> ligands were typed by polymerase chain reaction\u2010sequence specific oligonucleotide probes. We analyzed the effect of the number of missing KIR<\/jats:styled-content> ligands (Bw4, C1<\/jats:styled-content> and C2<\/jats:styled-content>) on clinical outcomes. A beneficial effect of missing KIR<\/jats:styled-content> ligand was not observed in both univariate and multivariate analysis. When we analyzed the effect of specific missing KIR<\/jats:styled-content> ligand on clinical outcomes, there was a trend that patients with missing A11<\/jats:styled-content> ligand had lower relapse rate (P<\/jats:italic>\u2009=\u20090.076). Therefore, we also conducted the analysis by including the group with missing KIR<\/jats:styled-content> ligands of Bw4, C1<\/jats:styled-content>, C2<\/jats:styled-content> and A11<\/jats:styled-content>. Patients with two or more than two missing KIR<\/jats:styled-content> ligands had a trend for better clinical outcome including reduced relapse (P<\/jats:italic>\u2009=\u2009055) and statistically significant in terms of reduced acute graft\u2010vs<\/jats:italic>\u2010host disease (aGVHD<\/jats:styled-content>) rate (P<\/jats:italic>\u2009=\u20090.013). In multivariate analysis, patients with two or more than two missing KIR<\/jats:styled-content> ligands had a statistically significant better clinical outcome in terms of reduced aGVHD<\/jats:styled-content> rate (HR<\/jats:styled-content>\u2009=\u20090.155, 95%CI<\/jats:styled-content>\u2009=\u20090.040\u20130.605, P<\/jats:italic>\u2009=\u20090.007). The association between clinical outcome with KIR<\/jats:styled-content> haplotypes, centromeric B haplotype and activating KIR<\/jats:styled-content> was not observed here. Although the sample size in this study is rather limited, these data can later be subjected to meta\u2010analysis to help reach the conclusion of the usefulness of this additional promising KIR<\/jats:styled-content> genotyping in various hematopoietic stem cell transplantation types.<\/jats:p>","DOI":"10.1111\/tan.12829","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T03:30:24Z","timestamp":1465356624000},"page":"422-431","source":"Crossref","is-referenced-by-count":6,"title":["The effect of missing KIR<\/scp> ligands, activating KIR<\/scp> genotype and haplotype on the outcome of T\u2010cell\u2010replete hematopoietic stem cell transplantation from HLA<\/scp>\u2010identical siblings in Thai patients"],"prefix":"10.1111","volume":"87","author":[{"given":"S.","family":"Khanuntong","sequence":"first","affiliation":[{"name":"Medical Microbiology Interdisciplinary Program, Graduate School Chulalongkorn University Bangkok Thailand"},{"name":"Histocompatibility and Immunogenetics Laboratory, National Blood Centre Thai Red Cross Society Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kuptawintu","sequence":"additional","affiliation":[{"name":"Histocompatibility and Immunogenetics Laboratory, National Blood Centre Thai Red Cross Society Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Upaisilpsathaporn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Poolchareon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Bunworasate","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Hirankarn","sequence":"additional","affiliation":[{"name":"Center of Excellence in Immunology and Immune\u2010mediated Diseases, Department of Microbiology, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00027"},{"key":"e_1_2_7_3_1","first-page":"225","article-title":"The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer","volume":"395","author":"Cichocki F","year":"2015","journal-title":"Curr Top Microbiol 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HLA\u2010matched sibling donor hematopoietic stem cell transplantation for myeloid malignancies","volume":"143","author":"Wang H","year":"2013","journal-title":"Swiss Med 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of KIR genes in HLA\u2010identical sibling hematopoietic stem cell transplantation in Thai patients with leukemia","volume":"95","author":"Wongwuttisaroj N","year":"2012","journal-title":"J Med Assoc 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