{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:40:58Z","timestamp":1788172858095,"version":"build-2803163510"},"reference-count":120,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"GRK","award":["1591-B2"],"award-info":[{"award-number":["1591-B2"]}]},{"name":"DFG Se","award":["581\/22-1"],"award-info":[{"award-number":["581\/22-1"]}]},{"name":"Mildred Scheel Foundation","award":["111091"],"award-info":[{"award-number":["111091"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Although the human immune system can recognize and eradicate tumor cells, tumors have also been shown to develop different strategies to escape immune surveillance, which has been described for the first time in different mouse models. The evasion of immune recognition was often associated with a poor prognosis and reduced survival of patients. During the last years the molecular mechanisms, which protect tumor cells from this immune attack, have been identified and appear to be more complex than initially expected. However, next to the composition of cellular, soluble and physical components of the tumor microenvironment, the tumor cells changes to limit immune responses. Of particular importance are classical and non\u2010classical human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) class I antigens, which often showed a deregulated expression in cancers of distinct origin. Furthermore, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I abnormalities were linked to defects in the interferon signaling, which have both been shown to be essential for mounting immune responses and are involved in resistances to T cell\u2010based immunotherapies. Therefore this review summarizes the expression, regulation, function and clinical relevance of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I antigens in association with the interferon signal transduction pathway and its role in adaptive resistances to immunotherapies.<\/jats:p>","DOI":"10.1111\/tan.12898","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T02:17:03Z","timestamp":1474597023000},"page":"213-220","source":"Crossref","is-referenced-by-count":57,"title":["Molecular mechanisms of <scp>HLA<\/scp> class I\u2010mediated immune evasion of human tumors and their role in resistance to immunotherapies"],"prefix":"10.1111","volume":"88","author":[{"given":"B.","family":"Seliger","sequence":"first","affiliation":[{"name":"Institute of Medical Immunology Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.06.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5059-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2015.09.028"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.04.005"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501657"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw168"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4971"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxw014"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2015.10.002"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800961506150805145120"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.01.002"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.4059"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.01.001"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.04.015"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.02.009"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446061"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.10.009"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.14.58"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.05.012"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01831.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-012-0125-8"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.05.006"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1016700"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2015-0029"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.04.006"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.05.008"},{"key":"e_1_2_12_29_1","first-page":"453","article-title":"Evolution of studies of HLA class I antigen processing machinery (APM) components in malignant cells","author":"Sabbatino F","year":"2013","journal-title":"Clin Transpl"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.6.961"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-011-1153-9"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-012-1321-6"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28338"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0567"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.03.003"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540304.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.12.007"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20000"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0811036"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.314"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2012.09.009"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0008"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0270-z"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2500"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445289"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0030"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1056>3.0.CO;2-K"},{"key":"e_1_2_12_48_1","first-page":"8647","article-title":"Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway","volume":"61","author":"Seliger B","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300954200"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.05.019"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-009-8123-8"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3198"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24557"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01390.x"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.676130"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.273"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044952"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.109"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2816"},{"key":"e_1_2_12_60_1","first-page":"3660","article-title":"Down\u2010regulation of the transporter for antigen presentation, proteasome subunits, and class I major histocompatibility complex in tumor cell lines","volume":"58","author":"Johnsen A","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.057001039.x"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-199407000-00002"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.094284"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3339"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005088"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-015-1774-5"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008684107"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103136"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103160"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602069113"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3471"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5587"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4029"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2014.01.009"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12328"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0098"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00097"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.26097"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404862"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.547"},{"key":"e_1_2_12_81_1","first-page":"2226","article-title":"Prognostic significance of serum sMICA levels in non\u2010small cell lung cancer","volume":"19","author":"Wang LP","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12562"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2015.04.001"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00173"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.02.012"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.04.010"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.103"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2016-0001"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.101"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000062"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006504"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0588-x"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-015-0392-7"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0414-x"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.02.004"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.10.009"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.4161\/21624011.2014.963413"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3271"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.02.001"},{"key":"e_1_2_12_100_1","first-page":"1354","article-title":"Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer","volume":"11","author":"Kline J","year":"2010","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-016-0129-x"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.05.001"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00421"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.01.006"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.2.100"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9414"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209434"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4316"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7556"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2114"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604958"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-010-0893-2"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8567"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1008805"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.08.096"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2703"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3789"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3015"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101324"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3175"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(96)10075-X"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12898","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T02:00:43Z","timestamp":1696212043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,22]]},"references-count":120,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/tan.12898"],"URL":"https:\/\/doi.org\/10.1111\/tan.12898","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,22]]}}}