{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:25:29Z","timestamp":1740176729597,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008107","name":"Buddhist Compassion Relief Tzu Chi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Chimerism is defined as the presence of 2 or more than 1 genetically distinct cell populations in an organism. Dispermic chimeras are derived from the fertilization of 1 or 2 matured nuclei by 2 sperms. We here report detection of a healthy and phenotypically normal female with normal ABO red blood cell typing in whom dispermic chimerism was suspected after 3 alleles were identified at multiple human leukocyte antigen (HLA) loci using molecular HLA analysis. Molecular HLA typing showed the donor to have 3 HLA\u2010A, \u2010B, \u2010C, \u2010DRB1, \u2010DQB1 and \u2010DPB1 alleles in blood, saliva and nail samples. In addition, 3 of her 9 short tandem repeat loci also showed to have 3 distinct alleles in blood, nail and saliva specimens. In all investigations, the third alleles were attributed to a dual paternal contribution. This case represents a dispermic chimerism, with 2 paternal and 1 maternal haplotypes variably distributed throughout body tissues in a healthy and phenotypically normal female without abnormalities in erythrocyte ABO blood group. The origin of this chimerism is probably due to the fertilization of a single egg and its polar body, or a parthenogenetic egg, by 2 sperms.<\/jats:p>","DOI":"10.1111\/tan.12954","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T02:20:43Z","timestamp":1484792443000},"page":"98-103","source":"Crossref","is-referenced-by-count":2,"title":["A dispermic chimerism detected in a Taiwanese potential unrelated hematopoietic stem cell donor"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7440-2318","authenticated-orcid":false,"given":"E. K. L.","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre Hualien Tzu Chi Hospital  Hualien Taiwan"},{"name":"Department of Laboratory Medicine Buddhist Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-4120","authenticated-orcid":false,"given":"S. G. E.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute and UCL Cancer Institute The Royal Free Campus  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.\u2010Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Medical Genetics Hualien Tzu Chi Hospital  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010P.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010P.","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre Hualien Tzu Chi Hospital  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre Hualien Tzu Chi Hospital  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb05991.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojped.2011.14019"},{"key":"e_1_2_6_4_1","first-page":"24","article-title":"46,XX, XY chimerism \u2013 a case report","volume":"55","author":"Aruna N","year":"2006","journal-title":"J Anat Soc India"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/(SICI)1096-8628(19960122)61:3<264::AID-AJMG11>3.0.CO;2-R","article-title":"Blood group chimerism in human multiple births is not rare","volume":"61","author":"Dijk van BA","year":"1996","journal-title":"Am J Med Genet"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.04304.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.10.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01711.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.01005.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199705000-00015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/chim.1.2.14301"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2007.00704.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcmj.2015.09.002"},{"key":"e_1_2_6_14_1","first-page":"17","volume-title":"The ACT cytogenetics Laboratory Manual","author":"Barch MJ","year":"1991"},{"volume-title":"ISCN 2013: An International System for Cytogenetic Nomenclature","year":"2013","author":"Shaffer LG","key":"e_1_2_6_15_1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-071423"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.68"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T15:25:39Z","timestamp":1696173939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,18]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/tan.12954"],"URL":"https:\/\/doi.org\/10.1111\/tan.12954","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"type":"print","value":"2059-2302"},{"type":"electronic","value":"2059-2310"}],"subject":[],"published":{"date-parts":[[2017,1,18]]}}}