{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:33:16Z","timestamp":1768818796389,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81001341"],"award-info":[{"award-number":["81001341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Background<\/jats:title>HLA<\/jats:styled-content>\u2010B*15:02<\/jats:italic> is a known biomarker for carbamazepine (CBZ<\/jats:styled-content>)\u2010induced Stevens\u2010Johnson syndrome and toxic epidermal necrolysis (SJS<\/jats:styled-content>\/TEN<\/jats:styled-content>) in some ethnic populations. The US FDA<\/jats:styled-content> recommends B*15:02<\/jats:italic> screening for Asian and other populations with a high prevalence of B*15:02<\/jats:italic> prior to treatment with CBZ<\/jats:styled-content> to prevent drug\u2010related SJS<\/jats:styled-content>\/TEN<\/jats:styled-content>.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>A total of 1607 blood samples were collected from volunteer blood donors who were ethnic minorities living in the Yunnan province of southwestern China, including 153 Yi, 193 Naxi, 167 Miao, 156 Lisu, 166 Derung, 211 Bai, 184 Hani, 198 Dai, and 179 Zhuang. The genetic diversity of the \nHLA<\/jats:styled-content>\u2010B*15:02<\/jats:italic> genes in the ethnic minority samples was examined using sequence based typing at high resolution.<\/jats:p><\/jats:sec>Results<\/jats:title>The allele frequencies of \nHLA<\/jats:styled-content>\u2010B*15:02<\/jats:italic> in the Yi, Naxi, Miao, Lisu, Derung, Bai, Hani, Dai, and Zhuang populations were 4.25%, 4.4%, 5.09%, 5.77%, 6.33%, 7.82%, 8.15%, 9.6%, and 15.36%, respectively. The frequencies of \nHLA<\/jats:styled-content>\u2010B*15:02<\/jats:italic> carriers in the Yi, Naxi, Miao, Lisu, Derung, Bai, Hani, Dai, and Zhuang populations were 8.5%, 8.8%, 9.58%, 10.9%, 12.65%, 15.64%, 16.3%, 18.69%, and 28.49%, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The \nHLA<\/jats:styled-content>\u2010B*15:02<\/jats:italic> allele frequencies indicated that the prevalence of B*15:02<\/jats:italic> was different among the different ethnic populations. Because the number of carriers of B*15:02<\/jats:italic> was high in some ethnic populations, larger studies are required to confirm these findings. The Zhuang population had the highest frequency of B*15:02<\/jats:italic> in this study. More attention should be paid to CBZ<\/jats:styled-content>\u2010induced SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> in Chinese minority populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tan.12970","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T03:46:36Z","timestamp":1487216796000},"page":"225-229","source":"Crossref","is-referenced-by-count":9,"title":["A study of HLA<\/scp>\u2010B*15:02<\/i> in 9 different Chinese ethnics: Implications for carbamazepine related SJS<\/scp>\/TEN<\/scp>"],"prefix":"10.1111","volume":"89","author":[{"given":"G. J.","family":"Ou","sequence":"first","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion, CAMS & PUMC Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion, CAMS & PUMC Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Ji","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion, CAMS & PUMC Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yu","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion, CAMS & PUMC Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion, CAMS & PUMC Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion, CAMS & PUMC Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion, CAMS & PUMC Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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