{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:23:40Z","timestamp":1789025020823,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Background<\/jats:title>Type 1 diabetes (T1D<\/jats:styled-content>) and celiac disease (CeD<\/jats:styled-content>) are 2 distinct diseases, but there is an increased risk of developing CeD<\/jats:styled-content> for T1D<\/jats:styled-content> patients. Both diseases are associated with HLA<\/jats:styled-content>\u2010class II<\/jats:styled-content> alleles, such as \nDQB1<\/jats:italic>\n<\/jats:styled-content>\n*02:01<\/jats:italic> and \nDQB1<\/jats:italic>\n<\/jats:styled-content>\n*03:02<\/jats:italic>; however, their risk contribution vary between the diseases.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>We genotyped \nHLA\u2010DRB1<\/jats:styled-content>\n<\/jats:italic> and \u2013\nDQB1<\/jats:styled-content>\n<\/jats:italic> in 215 patients with coexisting T1D<\/jats:styled-content> and CeD<\/jats:styled-content> identified from a T1D<\/jats:styled-content> cohort, and compared them to patients with T1D<\/jats:styled-content> (N\u2009=\u2009487) and CeD<\/jats:styled-content> (N\u2009=\u2009327), as well as healthy controls (N\u2009=\u2009368).<\/jats:p><\/jats:sec>Results<\/jats:title>The patients with coexisting T1D<\/jats:styled-content> and CeD<\/jats:styled-content> had an intermediate carrier frequency (72.8%) of the \nDRB1<\/jats:italic>\n<\/jats:styled-content>\n*03:01\u2010<\/jats:italic>\n\nDQB1<\/jats:italic>\n<\/jats:styled-content>\n*02:01\u2010<\/jats:italic>\n\nDQA1<\/jats:italic>\n<\/jats:styled-content>\n*05:01<\/jats:italic> haplotype compared to T1D<\/jats:styled-content> (64.1%) and CeD<\/jats:styled-content> (88.7%) patients. The \nDRB1<\/jats:italic>\n<\/jats:styled-content>\n*03:01\u2010<\/jats:italic>\n\nDQB1<\/jats:italic>\n<\/jats:styled-content>\n*02:01\u2010<\/jats:italic>\n\nDQA1<\/jats:italic>\n<\/jats:styled-content>\n*05:01\/<\/jats:italic>\n\nDRB1<\/jats:italic>\n<\/jats:styled-content>\n*04\u2010<\/jats:italic>\n\nDQB1<\/jats:italic>\n<\/jats:styled-content>\n*03:02\u2010<\/jats:italic>\n\nDQA1<\/jats:italic>\n<\/jats:styled-content>\n*03<\/jats:italic> haplotype combination, encoding DQ2<\/jats:styled-content>.5 and DQ8<\/jats:styled-content> molecules, was equally frequent among patients with both T1D<\/jats:styled-content> and CeD<\/jats:styled-content> (52.6%) and T1D<\/jats:styled-content> patients (46.8%) but significantly lower in CeD<\/jats:styled-content> patients (9.5%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Overall, the patients with coexisting T1D<\/jats:styled-content> and CeD<\/jats:styled-content> had an HLA<\/jats:styled-content> profile more similar to T1D<\/jats:styled-content> patients than CeD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tan.12986","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T04:07:24Z","timestamp":1488341244000},"page":"278-284","source":"Crossref","is-referenced-by-count":21,"title":["HLA<\/scp> class II<\/scp> alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-9269","authenticated-orcid":false,"given":"M. K.","family":"Viken","sequence":"first","affiliation":[{"name":"Department of Immunology Oslo University Hospital and University of Oslo Oslo Norway"},{"name":"Department of Medical Genetics University of Oslo and Oslo University Hospital Oslo Norway"},{"name":"Oslo Diabetes Research Centre Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Fl\u00e5m","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Oslo and Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Skrivarhaug","sequence":"additional","affiliation":[{"name":"Oslo Diabetes Research Centre Oslo Norway"},{"name":"Department of Paediatrics, Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"},{"name":"The Norwegian Childhood Diabetes Registry, Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Amundsen","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital and University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Sollid","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital and University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Drivvoll","sequence":"additional","affiliation":[{"name":"The Norwegian Childhood Diabetes Registry, Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Joner","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dahl\u2010J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Oslo Diabetes Research Centre Oslo Norway"},{"name":"Department of Paediatrics, Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A.","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital and University of Oslo Oslo Norway"},{"name":"Department of Medical Genetics University of Oslo and Oslo University Hospital Oslo Norway"},{"name":"Oslo Diabetes Research Centre Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S062"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.505931"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2883"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3245"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.04.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807917"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.600205.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1993.tb01998.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007732"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2337\/diab.44.6.608","article-title":"HLA\u2010DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody\u2010positive first\u2010degree relatives of patients with IDDM","volume":"44","author":"Pugliese A","year":"1995","journal-title":"Diabetes"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2005.03.021"},{"key":"e_1_2_6_15_1","first-page":"799","article-title":"Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin\u2010dependent diabetes mellitus","volume":"43","author":"Thomson G","year":"1988","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00867.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1331"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113965"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.320374"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.313940"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101179"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2016.1164144"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dcs15-2007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.01.016"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07125-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.88"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0932-0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200403000-00020"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.530502.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364377"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32834d09d4"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.4065\/80.11.1429"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021687"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00367.x"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:31:39Z","timestamp":1695979899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/tan.12986"],"URL":"https:\/\/doi.org\/10.1111\/tan.12986","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,28]]}}}