{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:17:35Z","timestamp":1758637055755,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>\n<jats:styled-content style=\"fixed-case\">FoxP3<\/jats:styled-content> and Vav1 are known to be involved in the development of regulatory T cells. Two polymorphic sites in the <jats:styled-content style=\"fixed-case\">FoxP3<\/jats:styled-content> promoter (rs3761548 and a (<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>)<jats:italic>\n<jats:sub>n<\/jats:sub>\n<\/jats:italic>\u2010dinucleotide repeat) and 2 single nucleotide polymorphisms in intron 1 of the Vav1 gene (rs2546133 and rs2617822) have been shown to correlate with gene expression levels. We investigated a potential impact of <jats:styled-content style=\"fixed-case\">FoxP3<\/jats:styled-content> and Vav1 genetic variants on kidney allograft failure using samples and data of the Collaborative Transplant Study. A cohort of 384 kidney transplant patients was tested. We found no significant association of <jats:styled-content style=\"fixed-case\">FoxP3<\/jats:styled-content> promoter rs3761548 or (<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>)<jats:italic>\n<jats:sub>n<\/jats:sub>\n<\/jats:italic> repeat length with presumed immunological graft failure. The genotype frequencies of Vav1 intron polymorphisms did not significantly differ between patients with graft failure and matched controls.<\/jats:p>","DOI":"10.1111\/tan.13049","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T02:12:47Z","timestamp":1493863967000},"page":"102-105","source":"Crossref","is-referenced-by-count":4,"title":["Assessing the impact of <scp>FoxP3<\/scp> and Vav1 gene polymorphisms on kidney allograft survival"],"prefix":"10.1111","volume":"90","author":[{"given":"M.","family":"Adamek","sequence":"first","affiliation":[{"name":"Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"D\u00f6hler","sequence":"additional","affiliation":[{"name":"Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science University of Baghdad  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fiedler","sequence":"additional","affiliation":[{"name":"Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Scherer","sequence":"additional","affiliation":[{"name":"Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Opelz","sequence":"additional","affiliation":[{"name":"Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-5989","authenticated-orcid":false,"given":"T. H.","family":"Tran","sequence":"additional","affiliation":[{"name":"Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000269725.74189.b9"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12653"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13395"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-003-0559-8"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2012.01561.x"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.01.028"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.02.008"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.105148"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102191"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000278"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2007.03.007"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2012.03.003"},{"key":"e_1_2_3_15_1","first-page":"218","article-title":"FOXP3 and TGF\u2010beta gene polymorphisms in allergic rhinitis","volume":"8","author":"Hassannia H","year":"2011","journal-title":"Iran J Immunol"},{"key":"e_1_2_3_16_1","first-page":"159","article-title":"Deer gender determination by polymerase chain reaction: validation study and application to tissues, bloodstains, and hair forensic samples from California","volume":"84","author":"Gilson A","year":"1998","journal-title":"Calif Fish Game"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00370.x"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03633.x"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029939"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.13049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.13049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T20:49:13Z","timestamp":1694378953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.13049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/tan.13049"],"URL":"https:\/\/doi.org\/10.1111\/tan.13049","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"type":"print","value":"2059-2302"},{"type":"electronic","value":"2059-2310"}],"subject":[],"published":{"date-parts":[[2017,5,3]]}}}