{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:19:27Z","timestamp":1791559167346,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Celiac disease is associated with the \nHLA\u2010DR3\u2010DQA1<\/jats:styled-content>*05:01\u2010DQB1<\/jats:styled-content>*02:01<\/jats:italic> and \nDR4\u2010DQA1<\/jats:styled-content>*03:01\u2010DQB1<\/jats:styled-content>*03:02<\/jats:italic> haplotypes. In addition, there are currently over 40 non\u2010HLA<\/jats:styled-content> loci associated with celiac disease. This study extends previous analyses on different HLA<\/jats:styled-content> haplotypes in celiac disease using next generation targeted sequencing.<\/jats:p>Included were 143 patients with celiac disease and 135 non\u2010celiac disease controls investigated at median 9.8\u2009years (1.4\u201018.3\u2009years). PCR<\/jats:styled-content>\u2010based amplification of HLA<\/jats:styled-content> and sequencing with Illumina MiSeq<\/jats:styled-content> technology were used for extended sequencing of the HLA<\/jats:styled-content> class II<\/jats:styled-content> haplotypes HLA\u2010DRB1<\/jats:styled-content>, DRB3<\/jats:styled-content>, DRB4<\/jats:styled-content>, DRB5<\/jats:styled-content>, DQA1<\/jats:styled-content> and DQB1<\/jats:styled-content>, respectively. Odds ratios were computed marginally for every allele and haplotype as the ratio of allelic frequency in patients and controls as ratio of exposure rates (RR<\/jats:styled-content>), when comparing a null reference with equal exposure rates in cases and controls.<\/jats:p>Among the extended HLA<\/jats:styled-content> haplotypes, the strongest risk haplotype for celiac disease was shown for \nDRB3<\/jats:styled-content>*01:01:02<\/jats:italic> in linkage with \nDQA1<\/jats:styled-content>*05:01\u2010DQB1<\/jats:styled-content>*02:01<\/jats:italic> (RR<\/jats:styled-content> = 6.34; P<\/jats:italic>\u2010value < .0001). In a subpopulation analysis, \nDRB3<\/jats:styled-content>*01:01:02\u2010DQA1<\/jats:styled-content>*05:01\u2010DQB1<\/jats:styled-content>*02:01<\/jats:italic> remained the most significant in patients with Scandinavian ethnicity (RR<\/jats:styled-content> = 4.63; P<\/jats:italic>\u2009<\u2009.0001) whereas \nDRB1<\/jats:styled-content>*07:01:01\u2010DRB4<\/jats:styled-content>*01:03:01\u2010DQA1<\/jats:styled-content>*02:01\u2010DQB1<\/jats:styled-content>*02:02:01<\/jats:italic> presented the highest risk of celiac disease among non\u2010Scandinavians (RR<\/jats:styled-content> = 7.94; P<\/jats:italic>\u2009=\u2009.011).<\/jats:p>The data also revealed 2 distinct celiac disease risk DR3\u2010DQA1*05:01\u2010DQB*02:01<\/jats:italic> haplotypes distinguished by either the DRB3*01:01:02<\/jats:italic> or DRB3*02:02:01<\/jats:italic> alleles, indicating that different DRB1*03:01\u2010DQB1*02:01<\/jats:italic> haplotypes confer different risk for celiac disease. The associated risk of celiac disease for \nDR3\u2010DRB3<\/jats:styled-content>*01:01:02\u2010DQA1<\/jats:styled-content>*05:01\u2010DQB1<\/jats:styled-content>*02:01<\/jats:italic> is predominant among patients of Scandinavian ethnicity.<\/jats:p>","DOI":"10.1111\/tan.13065","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T03:38:39Z","timestamp":1496720319000},"page":"95-101","source":"Crossref","is-referenced-by-count":23,"title":["Different DRB1<\/scp>*03:01\u2010DQB1<\/scp>*02:01<\/i> haplotypes confer different risk for celiac disease"],"prefix":"10.1111","volume":"90","author":[{"given":"S.","family":"Alshiekh","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University\/CRC Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Medicine King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. P.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Waltham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5.","family":"Lernmark","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University\/CRC Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. E.","family":"Geraghty","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Waltham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5. T.","family":"Naluai","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1435-1234","authenticated-orcid":false,"given":"D.","family":"Agardh","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University\/CRC Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12736"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.03.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12850"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.10.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2012.01941.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.345"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152476"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.998"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304110"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.102"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3268"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)90015-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.150"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043585"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.04.002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1101486"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00408469"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.05.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2014.08.206"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/338688"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01911.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.083964"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-19"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311713"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22287"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00696-7"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1387"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1115"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.13065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.13065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T20:49:06Z","timestamp":1694378946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.13065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/tan.13065"],"URL":"https:\/\/doi.org\/10.1111\/tan.13065","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,5]]}}}