{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:51:04Z","timestamp":1790743864295,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91542121"],"award-info":[{"award-number":["91542121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571603"],"award-info":[{"award-number":["81571603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401363"],"award-info":[{"award-number":["81401363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Genetic variation in HLA plays an important role in the pathogenesis of dermatomyositis (DM). The aim of this study was to investigate the association of HLA class II with DM in China. Two hundred and twenty\u2010four DM patients and 300 healthy controls were randomly enrolled at China\u2010Japan Friendship Hospital. High\u2010resolution typing of HLA\u2010DRB1 alleles was performed by sequencing based typing. The HLA\u2010DQA1 and HLA\u2010DQB1 alleles were determined by polymerase chain reaction sequence\u2010specific primers. The frequencies of <jats:italic>HLA\u2010DRB1*09:01<\/jats:italic> (28.6% vs 11.3%, <jats:italic>P<\/jats:italic> &lt; .0001, odds ratio, OR = 3.14, 95% confidence interval, CI = 2.47\u20103.99) and <jats:italic>HLA\u2010DRB1*12:01<\/jats:italic> (29.0% vs 11.0%, <jats:italic>P<\/jats:italic> &lt; .0001, OR = 3.30, 95% CI = 2.59\u20104.20) in DM patients were significantly higher than that in healthy controls. No significant difference was found in HLA\u2010DQA1 or DQB1 alleles between DM patients and healthy controls. Furthermore, DM patients with anti\u2010melanoma differentiation\u2010associated gene 5 antibody (anti\u2010MDA5) had a significantly higher frequency of <jats:italic>HLA\u2010DRB1*12:01<\/jats:italic> compared to that for patients without anti\u2010MDA5 (<jats:italic>P<\/jats:italic> &lt; .0001, OR = 4.77, 95% CI: 2.29\u20109.93). Multivariate binary logistic regression analysis was performed to identify the risk factors for interstitial lung disease. The <jats:italic>HLA\u2010DRB1*09:01<\/jats:italic> allele was a poor prognostic factor (<jats:italic>P<\/jats:italic> = .01, OR = 9.21, 95% CI: 1.47\u201057.50) for DM patients with anti\u2010MDA5 autoantibody. In summary, our findings indicate that <jats:italic>HLA\u2010DRB1*09:01<\/jats:italic> and <jats:italic>HLA\u2010DRB1*12:01<\/jats:italic> alleles may contribute to susceptibility of adult DM in Han Chinese population. In addition, the <jats:italic>DRB1*12:01<\/jats:italic> genotype is significantly associated with the presence of anti\u2010MDA5 antibody in DM patients.<\/jats:p>","DOI":"10.1111\/tan.13171","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T11:04:51Z","timestamp":1509966291000},"page":"354-359","source":"Crossref","is-referenced-by-count":28,"title":["Genetic association of HLA\u2010DRB1 multiple polymorphisms with dermatomyositis in Chinese population"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-2069","authenticated-orcid":false,"given":"JM","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences Capital Medical University  Beijing China"},{"name":"Department of Laboratory Medicine The Affiliated Southeast Hospital of Xiamen University  Zhangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YB","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics, Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QL","family":"Peng","sequence":"additional","affiliation":[{"name":"Peking University China\u2010Japan Friendship School of Clinical Medicine Department of Rheumatology, China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HB","family":"Yang","sequence":"additional","affiliation":[{"name":"Peking University China\u2010Japan Friendship School of Clinical Medicine Department of Rheumatology, China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JL","family":"Shi","sequence":"additional","affiliation":[{"name":"Peking University China\u2010Japan Friendship School of Clinical Medicine Department of Rheumatology, China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ML","family":"Gu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics, Chinese Academy of Sciences  Beijing China"},{"name":"Joint Laboratory for Translational Medicine Research Beijing Institute of Genomics, Chinese Academy of Sciences &amp; Liaocheng People's Hospital  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WM","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GC","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University China\u2010Japan Friendship School of Clinical Medicine Department of Rheumatology, China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05157-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05119.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21985"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085062"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2005.03.021"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000217525.82287.eb"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208119"},{"key":"e_1_2_1_9_1","first-page":"1768","article-title":"Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy","volume":"31","author":"Furuya T","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-14-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.ats3-00"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1993.tb01991.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12356"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10358"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep035"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3327"},{"key":"e_1_2_1_17_1","first-page":"198","article-title":"Association of HLA\u2010DRB1 alleles with polymyositis\/dermatomyositis in northern Chinese Hans","volume":"17","author":"Zhai N","year":"2002","journal-title":"Chin Med Sci J"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40051"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(95)80100-6"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34657"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1862"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.12.1398"},{"key":"e_1_2_1_23_1","first-page":"918","article-title":"Anti\u2010glucose\u20106\u2010phosphate isomerase, anti\u2010cyclic citrullinated peptide antibodies and HLA\u2010DRB1 genotypes in Japanese patients with early rheumatoid arthritis","volume":"26","author":"Furuya T","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000189818.63141.8c"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401220"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.08.002"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.7.2103110"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-012-0663-4"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22728"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.13171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.13171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T01:07:54Z","timestamp":1696036074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.13171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,20]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/tan.13171"],"URL":"https:\/\/doi.org\/10.1111\/tan.13171","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,20]]}}}