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This study examined the relationship between KIR gene content and clinical outcomes including the control of opportunistic infections such as cytomegalovirus in the setting of HLA\u2010matched sibling HSCT in an Australian cohort. The presence of the KIR B haplotype which contain more activating receptors in the donor, in particular centromeric B haplotype genes (Cen\u2010B), was associated with improved overall survival of patients with acute myeloid leukaemia undergoing sibling HSCT and receiving myeloablative conditioning. Donor Cen\u2010B haplotype was also associated with reduced acute GvHD grades II to IV whereas donor telomeric\u2010B haplotype was associated with decreased incidence of CMV reactivation. In contrast, we were not able to show a reduced rate of relapse when the donor had KIR Cen\u2010B; however, relapse with a donor Cen\u2010A haplotype was a competing risk factor to poor overall survival. Here, we show that the presence of donor activating KIR led to improved outcome for the patient, potentially through reduced relapse rates and decreased incidence of acute GvHD translating to improved overall survival.<\/jats:p>","DOI":"10.1111\/tan.13327","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T04:20:30Z","timestamp":1529986830000},"page":"74-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Activating killer\u2010cell immunoglobulin\u2010like receptor haplotype influences clinical outcome following HLA\u2010matched sibling haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7497-6477","authenticated-orcid":false,"given":"Susan L.","family":"Heatley","sequence":"first","affiliation":[{"name":"University of Melbourne  Melbourne VIC Australia"},{"name":"Australian Red Cross Blood Service  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Mullighan","sequence":"additional","affiliation":[{"name":"St Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Doherty","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Danner","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service  Adelaide SA Australia"},{"name":"Royal Adelaide and Queen Elizabeth Hospitals, SA Pathology  Adelaide SA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine M.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Hahn","sequence":"additional","affiliation":[{"name":"Royal Adelaide and Queen Elizabeth Hospitals, SA Pathology  Adelaide SA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Szer","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne VIC Australia"},{"name":"Royal Melbourne Hospital  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Schwarer","sequence":"additional","affiliation":[{"name":"Alfred Hospital  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Bradstock","sequence":"additional","affiliation":[{"name":"Westmead Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy C.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Bardy","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service  Adelaide SA Australia"},{"name":"Royal Adelaide and Queen Elizabeth Hospitals, SA Pathology  Adelaide SA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Brooks","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/358066a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.597"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068440"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.00126.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"Parham P. 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