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In unrelated hematopoietic stem cell transplantation (HSCT) in 688 patients with hematological malignancies we compared antitumor efficacy of transplant in three models including the level of: (a) donor\u2010recipient HLA class I mismatch, (b) KIR\u2010ligand mismatch, (c) post\u2010transplant cognate HLA:KIR pairing. The effects were directly compared in multivariate models with backward elimination including all three effects in initial model. In final multivariate model HLA mismatch and KIR\u2010ligand mismatch levels were eliminated and HLA:KIR\u2010dependent NK cell licensing effect remained independent prognostic factor for DFS, relapse\/progression incidence, and overall survival (OS). These results suggested that NK cell licensing via cognate HLA:KIR pairs is primarily functional in cancer immunosurveillance in HSCT.<\/jats:p>","DOI":"10.1111\/tan.13386","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T07:44:31Z","timestamp":1535701471000},"page":"42-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of donor HLA class I mismatch, KIR\u2010ligand mismatch and HLA:KIR pairings in hematological malignancy relapse after unrelated hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"92","author":[{"given":"Elzbieta","family":"Graczyk\u2010Pol","sequence":"first","affiliation":[{"name":"Department of Immunogenetics Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rogatko\u2010Koros","sequence":"additional","affiliation":[{"name":"Department of 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