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This highly specific immune function is impaired following hematopoietic stem cell transplantation (HSCT) for a timespan of several months needed for the maturation of T\u2010cells. Especially, the progression of HCMV disease in immunocompromised patients induces life\u2010threatening situations. Therefore, the need for a new immune system that delivers vital and potent CD8+ T\u2010cells carrying TCRs that recognize even one human cytomegalovirus (HCMV) peptide\/HLA molecule and clear the viral infection long term becomes obvious. The transcription and translation of HCMV proteins in the lytic cycle is a precisely regulated cascade of processes, therefore, it is a highly sensitive challenge to adjust the exact time point of HCMV\u2010peptide recruitment over self\u2010peptides. We utilized soluble HLA technology in HCMV\u2010infected fibroblasts and sequenced naturally <jats:italic>sHLA\u2010A*24:02<\/jats:italic> presented HCMV\u2010derived peptides. One peptide of 14 AAs length derived from the IE2 antigen induced the strongest T\u2010cell responses; this peptide can be detected with a low ranking score in general peptide prediction databanks. 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