{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:57:36Z","timestamp":1771232256392,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>We describe a unique ABO compatible and 9\/10 HLA\u2010matched case of successful allogeneic hematopoietic cell transplantation (HCT) after effective desensitization of a strong anti\u2010HLA\u2010A24 donor\u2010specific antibody (DSA) with mean fluorescence intensity of approximately 18\u2009000. Due to absence of a suitable matched unrelated donor the patient sibling was considered the best available donor, and it was decided to desensitize patient prior to transplant. The strength of HLA\u2010A24 DSA slowly decreased over the course of treatment, necessitating a total of 23 sessions of therapeutic plasma exchange in order to bring the DSA strength to undetectable levels, followed by a successful transplant. In summary, the outcome of this case shows effective application of desensitization treatment to remove strong DSA in HCT patients.<\/jats:p>","DOI":"10.1111\/tan.13627","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T15:14:47Z","timestamp":1563376487000},"page":"307-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effective desensitization for a strong donor\u2010specific HLA antibody in a case of HLA\u2010mismatched allogeneic hematopoietic cell transplantation"],"prefix":"10.1111","volume":"94","author":[{"given":"Maneesh K.","family":"Misra","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Chicago Medicine  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago Medicine  Chicago 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