{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:29:51Z","timestamp":1790512191362,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["#001"],"award-info":[{"award-number":["#001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008224","name":"Funda\u00e7\u00e3o da Universidade Federal do Paran\u00e1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>HLA\u2010E, a class I nonclassical HLA molecule, is expressed in all tissues and is involved in the regulation of both innate (by interaction with the CD94\/NKG2 receptor expressed mainly in NK cells) and adaptive immunity (by interaction with T CD8<jats:sup>+<\/jats:sup> cells), suggesting a possible role in the solid organ transplantation context. Transplanted patients with chronic kidney disease and their respective donors (N = 107 pairs) were genotyped for exons 2 and 3 of the <jats:italic>HLA\u2010E<\/jats:italic> locus by sequence\u2010based typing (SBT). Groups' genotype frequencies were compared regarding episodes of clinical rejection by global G test, and binary logistic regression was made to demonstrate the contribution of genetic variables vs epidemiological variables. Comparisons of donors' genotype frequencies showed significant differences (<jats:italic>P<\/jats:italic> =\u2009.0230), <jats:italic>revealing a protective profile of E*01:01\/*01:01<\/jats:italic> compared to the other genotypes (<jats:italic>P<\/jats:italic> =\u2009.0099; OR = 0.3088; CI [95%] = 0.1333\u20100.7157). The same happened when the aforementioned genotype was combined with the E*01:01\/*01:01 recipients' genotype (<jats:italic>P<\/jats:italic> =\u2009.0065; OR = 0.1760; CI [95%] = 0.0517\u20100.5987). A binary logistic regression analysis was performed, and, of all variables considered, only two were included in the resulting model (<jats:italic>P<\/jats:italic> =\u2009.007; R<jats:sup>2<\/jats:sup> Cox and Snell = 0.243; R<jats:sup>2<\/jats:sup> Nagelkerke = 0.328)\u2014 \u201cEnd\u2010Stage Renal Disease\u201d and \u201c<jats:italic>HLA<\/jats:italic> class II Mismatches.\u201d A protective profile (<jats:italic>E*01:01\/*01:01<\/jats:italic>) was observed between the recipients and donors, suggesting a possible impact of the <jats:italic>HLA\u2010E<\/jats:italic> genotype in rejection episodes.<\/jats:p>","DOI":"10.1111\/tan.13806","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T06:06:25Z","timestamp":1579241185000},"page":"457-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["HLA\u2010E genotyping and its relevance in kidney transplantation outcome"],"prefix":"10.1111","volume":"95","author":[{"given":"Bruna L. M.","family":"de Miranda","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica e Histocompatibilidade do Departamento de Gen\u00e9tica da Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u00f3rgia F.","family":"Gelmini","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica e Histocompatibilidade do Departamento de Gen\u00e9tica da Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Risti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica e Histocompatibilidade do Departamento de Gen\u00e9tica da Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Hauer","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica e Histocompatibilidade do Departamento de Gen\u00e9tica da Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Samuel","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica e Histocompatibilidade do Departamento de Gen\u00e9tica da Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria M. M. S.","family":"Roxo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica e Histocompatibilidade do Departamento de Gen\u00e9tica da Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Gra\u00e7a","family":"Bicalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica e Histocompatibilidade do Departamento de Gen\u00e9tica da Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-9707","authenticated-orcid":false,"given":"Danielle","family":"Malheiros","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular Humana do Departamento de Gen\u00e9tica da Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.07.006"},{"issue":"3","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.4049\/jimmunol.141.3.897","article-title":"HLA\u2010E a novel HLA class I gene expressed in resting T lymphocytes","volume":"141","author":"Koller BH","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-2-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01138.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35869"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.15.4250"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324432"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-011-0137-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00427-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834449100"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/907092"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12478"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208268200"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.10.4951"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(00)00190-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270517"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70014-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.5019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020797"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-002-0526-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.07.011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01832.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181bbb8fe"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000244598.92049.dd"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b0e79e"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.01.011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.07.010"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/352160"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.19.5444"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532296"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.09.003"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007041"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix638"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(99)00140-8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01203.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.11.037"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.13806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.13806","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.13806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:45:52Z","timestamp":1694047552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.13806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,3]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/tan.13806"],"URL":"https:\/\/doi.org\/10.1111\/tan.13806","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,3]]},"assertion":[{"value":"2019-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}