{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:09:56Z","timestamp":1792130996058,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>Some HLA alleles have been shown to be associated with susceptibility to cytomegalovirus (CMV) disease incidence in vitro. The objective of this study was to identify correlations between donor HLA allotypes and CMV disease incidence in patients with acute myeloid leukemia who had undergone allogeneic hematopoietic stem cell transplantation (HSCT). Methods and materials we retrospectively analyzed the medical records of 613 donors and recipients with acute myeloid leukemia who had received an allogeneic HSCT from matched sibling (n = 260), unrelated (n = 168), or haploidentical (n = 186) donors, from 2012 to 2017. The HLA\u2010A, \u2010B, \u2010C, and \u2010DRB1 allotypes in the donors were determined using sequence\u2010based typing. Overall, CMV disease incidence was significantly associated with three genotype alleles, <jats:italic>HLA\u2010A*30:04:01G<\/jats:italic>, \u2010<jats:italic>B*51:01:01G<\/jats:italic>, and <jats:italic>\u2010DRB1*09:01:02G<\/jats:italic>. In the donor CMV IgG seropositive subgroup, CMV disease incidence was significantly associated with <jats:italic>HLA\u2010B*51:01:01G<\/jats:italic> and <jats:italic>\u2010DRB1*09:01:02G<\/jats:italic>. In the IgG seropositive donors in the unrelated allo\u2010HSCT subgroup CMV disease incidence was also significantly associated with <jats:italic>HLA\u2010B*51:01:01G<\/jats:italic>. In the CMV seropositive donors in the haploidentical allo\u2010HSCT subgroup, the incidence of CMV disease was significantly associated with <jats:italic>HLA\u2010A*24:02:01G<\/jats:italic> and <jats:italic>\u2010DRB1*09:01:02G<\/jats:italic>. <jats:italic>HLA\u2010DRB1*13:02:01G<\/jats:italic> was a protective marker among IgG seropositive donors in the unrelated allo\u2010HSCT recipient category. Discussion and conclusions The incidence of CMV disease among HSCT recipients varies according to donor HLA alleles and the donor CMV IgG serostatus. Certain donor HLA alleles can be considered to be risk or protective markers. Donors' HLA types and CMV IgG serostatus should be considered in donor selection.<\/jats:p>","DOI":"10.1111\/tan.13966","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T12:30:51Z","timestamp":1591533051000},"page":"445-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Specific donor HLA allotypes as predictors of cytomegalovirus disease risk in acute myeloid leukemia"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-4693","authenticated-orcid":false,"given":"Gi\u2010June","family":"Min","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Je","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-2138","authenticated-orcid":false,"given":"Tai\u2010Gyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Catholic Hematopoietic Stem Cell Bank College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Seok","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Microbiology College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Joo","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Microbiology College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3630-3364","authenticated-orcid":false,"given":"In\u2010Cheol","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Microbiology College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Catholic Hematopoietic Stem Cell Bank College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seug Yun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Ho","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Sik","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Seong","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Ki","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok\u2010Goo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Leukemia Research Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00271"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19227"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/6.2.156"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01591"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01466.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2017.52.3.174"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-010-9653-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.09.029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.A30402"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1140"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.01.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12254"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093082"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.10.017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01151.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7347"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-12"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2010.11.011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx050"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679639"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.10.017"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00289-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-203307"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705699"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.403"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0369-0"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.273"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705648"},{"key":"e_1_2_8_30_1","first-page":"78","article-title":"Risk factors for the development of cytomegalovirus disease after allogeneic stem cell transplantation","volume":"91","author":"Ljungman P","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112666"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03971.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000304"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.118018"},{"issue":"2","key":"e_1_2_8_35_1","first-page":"219","article-title":"Differential association of HLA\u2010DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide","volume":"25","author":"Furuya T","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20608"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508097818"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.13966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.13966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.13966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:15:42Z","timestamp":1693930542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.13966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/tan.13966"],"URL":"https:\/\/doi.org\/10.1111\/tan.13966","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,4]]},"assertion":[{"value":"2020-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}