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In this review, we focus on the role of maternal T cells and myeloid cells (macrophages, dendritic cells) in pregnancy and their interaction with trophoblasts. To retain immunologic tolerization, trophoblasts evade immune recognition by T cells and produce factors that modulate their phenotype and function. On top of that, the local environment at the maternal\u2010fetal interface favors expansion of regulatory T cells. Macrophages and dendritic cells are essential in maintaining a healthy pregnancy. They produce soluble factors and act as antigen\u2010presenting cells, thereby interacting with T cells. Herein, M2 macrophages, immature dendritic cells, CD4\n                    <jats:sup>+<\/jats:sup>\n                    Th2 cells, and regulatory T cells represent an axis that maintains a local immune tolerant environment. We consider outstanding issues concerning these cell types and their pathways, which need to be addressed in future investigations. Data from recent single\u2010cell sequencing experiments of the placental bed, to study heterogeneity of maternal immune cells and to predict cell\u2010cell interactions, are discussed. Novel ways for long\u2010term culturing of primary trophoblasts allow for cell\u2010cell interaction studies in a functional way. Future directions should include study of the functionality of currently known and newly identified decidual immune cell subsets in healthy and complicated pregnancies, and their interaction with and modulation by trophoblast cells.\n                  <\/jats:p>","DOI":"10.1111\/tan.14055","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T22:52:41Z","timestamp":1598395961000},"page":"561-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Got your mother in a whirl: The role of maternal T cells and myeloid cells in pregnancy"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9648-4227","authenticated-orcid":false,"given":"Michael","family":"Eikmans","sequence":"first","affiliation":[{"name":"Department of Immunology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"van der Zwan","sequence":"additional","affiliation":[{"name":"Department of Immunology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans H. 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