{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:25:13Z","timestamp":1771943113091,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009727","name":"Dr P H\u00e5kanssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Most patients with celiac disease are positive for either <jats:italic>HLA\u2010DQA1*05:01\u2010DQB1*02<\/jats:italic> (DQ2.5) or <jats:italic>DQA1*03:01\u2010DQB1*03:02<\/jats:italic> (DQ8). Remaining few patients are usually <jats:italic>DQA1*02:01\u2010DQB1*02<\/jats:italic> (DQ2.2) carriers. Screenings of populations with high frequencies of these HLA\u2010DQA1\u2010DQB1 haplotypes report a 1% to 3% celiac disease prevalence. The aim was to determine the prevalence of HLA\u2010DQ risk haplotypes for celiac disease in Ethiopian children. Dried blood spots collected from 1193 children from the Oromia regional state of Ethiopia were genotyped for HLA\u2010DQA1 and DQB1 genotyping using an asymmetric polymerase chain reaction (PCR) and a subsequent hybridization of allele\u2010specific probes. As references, 2000 previously HLA\u2010genotyped children randomly selected from the general population in Sweden were included. DQ2.2 was the most common haplotype and found in 15.3% of Ethiopian children, which was higher compared with 6.7% of Swedish references (<jats:italic>P<\/jats:italic> &lt;\u2009.0001). Opposed to this finding, DQ2.5 and DQ8 occurred in 9.7% and 6.8% of Ethiopian children, which were less frequent compared with 12.8% and 13.1% of Swedish references, respectively (<jats:italic>P<\/jats:italic> &lt;\u2009.0001). The DQ2.5\u2010<jats:italic>trans<\/jats:italic> genotype encoded by <jats:italic>DQA1*05\u2010DQB1*03:01<\/jats:italic> in combination with DQ2.2 occurred in 3.6% of Ethiopian children, which was higher compared with 1.3% of Swedish references (<jats:italic>P<\/jats:italic> &lt;\u2009.0001). However, when children with moderate high to very high\u2010risk HLA genotypes were grouped together, there was no difference between Ethiopian children and Swedish references (27.4% vs 29.0%) (<jats:italic>P<\/jats:italic> =\u2009.3504). The frequency of HLA risk haplotypes for celiac disease is very similar in Ethiopian and Swedish children. This finding of importance will be useful in future screening of children for celiac disease in Ethiopia.<\/jats:p>","DOI":"10.1111\/tan.14119","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T07:05:42Z","timestamp":1603436742000},"page":"681-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Distribution of <scp>HLA\u2010DQ<\/scp> risk genotypes for celiac disease in Ethiopian children"],"prefix":"10.1111","volume":"96","author":[{"given":"Adugna N.","family":"Gudeta","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Ramelius","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taye T.","family":"Balcha","sequence":"additional","affiliation":[{"name":"Clinical Infection Medicine, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alemayehu","family":"Girma","sequence":"additional","affiliation":[{"name":"Adama Hospital Medical College  Adama Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Ilonen","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory, Institute of Biomedicine University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1435-1234","authenticated-orcid":false,"given":"Daniel","family":"Agardh","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000946"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i12.1365"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12605"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90912-V"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(03)00027-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1430253"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.1.187"},{"key":"e_1_2_9_9_1","first-page":"5409653","article-title":"Presence of DQ2.2 associated with DQ2.5 increases the risk for celiac disease","volume":"2016","author":"Almeida LM","year":"2016","journal-title":"Autoimmune Dis"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00532-X"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1489"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31818c52cc"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814531479"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3389\/fped.2019.00357","article-title":"Changing pattern of childhood celiac disease epidemiology: contributing factors","volume":"7","author":"Popp A","year":"2019","journal-title":"Front Pediatr"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12986"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-38-10"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12373"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i20.6302"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb02971.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1074-0"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181b477a6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.09.008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12327"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1813-4"},{"issue":"5","key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/sjg.SJG_551_17","article-title":"Genetic susceptibility for celiac disease is highly prevalent in the Saudi population","volume":"24","author":"Al\u2010Hussaini A","year":"2018","journal-title":"Saudi J Gastroenterol"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12857"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2008.10.018"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01772.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0094"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2609"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.320374"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360855"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojgen.2014.42013"},{"issue":"6","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.dld.2009.09.004","article-title":"HLA\u2010DQ2 and \u2010DQ8 genotypes in celiac and healthy Libyan children","volume":"42","author":"Alarida K","year":"2010","journal-title":"Dig Liver Dis"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.580609.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.00103.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-188"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-2803.201800000-16"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.444"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618765506"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.14119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.14119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.14119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T12:52:06Z","timestamp":1693831926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.14119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/tan.14119"],"URL":"https:\/\/doi.org\/10.1111\/tan.14119","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,30]]},"assertion":[{"value":"2020-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}