{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:10:20Z","timestamp":1778721020399,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["CUHK M14108719"],"award-info":[{"award-number":["CUHK M14108719"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>The coronavirus disease 2019 (COVID\u201019) is a highly infectious disease caused by SARS\u2010CoV\u20102. Since its first report in December 2019, COVID\u201019 has evolved into a global pandemic causing massive healthcare and socioeconomic challenges. HLA system is critical in mediating anti\u2010viral immunity and recent studies have suggested preferential involvement of HLA\u2010B in COVID\u201019 susceptibility. Here, by investigating the HLA\u2010B genotypes in 190 unrelated Chinese patients with confirmed COVID\u201019, we identified a significant positive association between the B22 serotype and SARS\u2010CoV\u20102 infection (<jats:italic>p<\/jats:italic> = 0.002, Bonferroni\u2010corrected <jats:italic>p<\/jats:italic> = 0.032). Notably, the B22 serotype has been consistently linked to susceptibility to other viral infections. These data not only shed new insights into SARS\u2010CoV\u20102 pathogenesis and vaccine development but also guide better infection prevention\/control.<\/jats:p>","DOI":"10.1111\/tan.14135","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T09:22:42Z","timestamp":1605172962000},"page":"127-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Association of <scp>HLA\u2010B22<\/scp> serotype with <scp>SARS\u2010CoV<\/scp>\u20102 susceptibility in Hong Kong Chinese patients"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-2915","authenticated-orcid":false,"given":"Yuk\u2010Lin","family":"Yung","sequence":"first","affiliation":[{"name":"Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Keung","family":"Cheng","sequence":"additional","affiliation":[{"name":"Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoi\u2010Yun","family":"Chan","sequence":"additional","affiliation":[{"name":"Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny T.","family":"Xia","sequence":"additional","affiliation":[{"name":"Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin\u2010Mang","family":"Lau","sequence":"additional","affiliation":[{"name":"Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond S. M.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Prince of Wales Hospital, The Chinese University of Hong Kong  Hong Kong China"},{"name":"Sir Y. K. Pao Centre for Cancer Prince of Wales Hospital  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan K. L.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Pamela Youde Nethersole Eastern Hospital  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond W.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Pamela Youde Nethersole Eastern Hospital  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice C. C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pathology United Christian Hospital  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eudora Y. D.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Pathology United Christian Hospital  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze\u2010Fai","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Medicine Tuen Mun Hospital  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer N. S.","family":"Leung","sequence":"additional","affiliation":[{"name":"Hong Kong Red Cross Blood Transfusion Service  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk\u2010Kwong","family":"Lee","sequence":"additional","affiliation":[{"name":"Hong Kong Red Cross Blood Transfusion Service  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret H. L.","family":"Ng","sequence":"additional","affiliation":[{"name":"Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong  Hong Kong China"},{"name":"State Key Laboratory of Translational Oncology The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105948"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/421523"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-4-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00510-20"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13941"},{"key":"e_1_2_6_7_1","volume-title":"Clinical Management of COVID\u201019: Interim Guidance","author":"World Health Organization","year":"2020"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.10.006"},{"issue":"1","key":"e_1_2_6_9_1","first-page":"D783","article-title":"Allele frequency net database (AFND) 2020 update: gold\u2010standard data classification, open access genotype data and new query tools","volume":"48","author":"Gonzalez\u2010Galarza FF","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/378071"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270136"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13956"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328362018f"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02355-3"},{"key":"e_1_2_6_16_1","article-title":"Structural similarity of SARS\u2010CoV2 Mpro and HCV NS3\/4A proteases suggests new approaches for identifying existing drugs useful as COVID\u201019 therapeutics","author":"Bafna K","year":"2020","journal-title":"ChemRxiv"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30057-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0148-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00349"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.14135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.14135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.14135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:31:29Z","timestamp":1693765889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.14135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/tan.14135"],"URL":"https:\/\/doi.org\/10.1111\/tan.14135","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}