{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:20:59Z","timestamp":1792794059473,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573206"],"award-info":[{"award-number":["81573206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019HC0060"],"award-info":[{"award-number":["2019HC0060"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>The host immune system plays an important role in infectious diseases and cancers. The heterodimer formed by transporter associated with antigen presenting (TAP)1 and TAP2 is responsible for intracellular peptide loading onto MHC\u2010I molecules. Studies have shown that single\u2010nucleotide polymorphisms (SNPs) in TAP genes might affect the expression and function of TAP and be associated with cancer risk. We aimed to investigate the association of SNPs in the <jats:italic>TAP1<\/jats:italic> and <jats:italic>TAP2<\/jats:italic> genes with cervical intraepithelial neoplasia (CIN) and cervical cancer (CC) in a Chinese Han population. Six SNPs in the <jats:italic>TAP1<\/jats:italic> gene and seven in the <jats:italic>TAP2<\/jats:italic> gene were selected. The 13 SNPs were genotyped in 1255 healthy individuals, 575 patients with CIN and 1034 patients with CC using the SNaPshot assay. The association between these SNPs and CIN and CC risk was analysed. The allelic and genotypic distributions of rs41549617 and rs1135216 showed significant differences between the control and CC groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0038). The T allele of rs41549617 was associated with a decreased risk of CC (OR\u00a0=\u00a00.476, 95%CI: 0.286\u20130.791). Moreover, the G allele of rs1135216 appears to be associated with a decreased risk of CC (OR\u00a0=\u00a00.746; 95%CI: 0.632\u20130.881). The allele and genotype distribution of rs241441 showed a significant difference between the control and CC groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0038), and the rs241441 G allele was associated with an increased risk of CC (OR\u00a0=\u00a01.232, 95%CI: 1.092\u20131.398). In addition, the results of the association between TAP alleles and CC showed that <jats:italic>TAP1*020101<\/jats:italic> and <jats:italic>TAP1*0301<\/jats:italic> have an association with CC (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002, respectively). Our results demonstrate that the <jats:italic>TAP1<\/jats:italic> and <jats:italic>TAP2<\/jats:italic> genes are associated with CC in the Chinese Han population.<\/jats:p>","DOI":"10.1111\/tan.14333","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T14:18:45Z","timestamp":1622297925000},"page":"23-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population"],"prefix":"10.1111","volume":"98","author":[{"given":"Jia","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Immunogenetics, Institute of Medical Biology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Kunming 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