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Pathological HLA\u2010G expression later in life might contribute to immune escape of various cancers. We studied the still controversial role of HLA\u2010G in colorectal carcinoma (CRC) using the MEM\u2010G\/1 antibody and a tissue microarray series of CRC tumors (<jats:italic>n<\/jats:italic>\u00a0=\u2009317). HLA\u2010G expression appeared in 20% of the tumors and showed high intratumoral heterogeneity. HLA\u2010G positivity was associated with better differentiation (p\u00a0=\u00a00.002) and non\u2010mucinous histology (p\u00a0=\u00a00.008). However, HLA\u2010G expression alone showed no prognostic value: 5\u2010years disease\u2010specific survival among patients with HLA\u2010G expression was 68.9% (95% CI: 62.7%\u201375.0%) compared to 74.8% (95% CI: 63.2%\u201386.3%) among those without expression. These results support a modulatory role of HLA\u2010G in CRC.<\/jats:p>","DOI":"10.1111\/tan.14334","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T14:23:00Z","timestamp":1622298180000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["HLA<scp>\u2010G<\/scp> expression correlates with histological grade but not with prognosis in colorectal carcinoma"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-9975","authenticated-orcid":false,"given":"Tuomas","family":"Kaprio","sequence":"first","affiliation":[{"name":"Department of Surgery University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Translational Cancer Medicine Research Program, Faculty of Medicine University of Helsinki  Helsinki 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