{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:01:53Z","timestamp":1747188113643,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>The HLA\u2010DPB1 locus has been demonstrated to have a significant role on patients' outcome after allogeneic HSCT, and the so\u2010called T\u2010cell epitope (TCE) algorithm has been incorporated in international guidelines for the selection of unrelated donors. The purpose of the present study is to measure, through a national survey conducted on behalf of the Associazione Italiana di Immunogenetica e Biologia dei Trapianti (AIBT), the extent of awareness and use of HLA\u2010DPB1 TCE\u2010based algorithms during the donor search. 89% of the HLA laboratories answered to a short questionnaire and the results showed a progressive increase of the laboratories typing DPB1 in patients and their potential donors during the search (from 44% to 79% during the 2010\u20132019 period) as well as the application of a TCE\u2010based algorithm for the donor choice whenever possible (from 24% to 65% during the same period). The DP\u2010permissiveness status is detailed in the official HLA typing report by 12%, 32% and 50% of laboratories in 2010, 2015 and 2019, respectively. The present data indicate an encouraging raise in the awareness of the HLA\u2010DPB1 role in unrelated donor selection; noteworthy, mentioning the TCE\u2010based permissiveness status in the HLA typing report of each potential unrelated donor represents a notable mean to raise awareness among transplant physicians and to support them in their task of choosing the best donor. Nonetheless, despite the compelling evidence of the predictive ability of TCE\u2010based algorithms, further efforts are still needed to extend its application to all transplant centers in Italy.<\/jats:p>","DOI":"10.1111\/tan.14347","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T04:22:00Z","timestamp":1624335720000},"page":"114-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Use of <scp>DPB1<\/scp> T\u2010cell epitope algorithm among italian transplant centers: A survey on behalf of Associazione Italiana di Immunogenetica e Biologia dei Trapianti"],"prefix":"10.1111","volume":"98","author":[{"given":"Roberto","family":"Crocchiolo","sequence":"first","affiliation":[{"name":"Servizio di Immunoematologia e Medicina Trasfusionale ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Mele","sequence":"additional","affiliation":[{"name":"Laboratorio HLA e processazione cellule staminali ematopoietiche Azienda Ospedaliera SS Antonio e Biagio e C Arrigo, Alessandria, Italy; Treasurer, Associazione Italiana di Immunogenetica e Biologia dei Trapianti, AIBT  Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Testi","sequence":"additional","affiliation":[{"name":"Secretary, Associazione Italiana di Immunogenetica e Biologia dei Trapianti, AIBT  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariadele","family":"Scollo Chiara","sequence":"additional","affiliation":[{"name":"Ematologia, Ospedale San Gerardo ASST  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Murgia","sequence":"additional","affiliation":[{"name":"SC laboratorio di istocompatibilit\u00e0 EO Ospedali Galliera  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Rossi","sequence":"additional","affiliation":[{"name":"UOSD Immunogenetica e Manipolazione cellule staminali emopoietiche Ospedale ''Guglielmo da Saliceto''  Piacenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-3314","authenticated-orcid":false,"given":"Cinzia","family":"Vecchiato","sequence":"additional","affiliation":[{"name":"Transfusion Service, San Maurizio Regional Hospital  Bolzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Grammatico","sequence":"additional","affiliation":[{"name":"UOC Laboratorio di Genetica Medica, Ospedale San Camillo  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donata","family":"Mininni","sequence":"additional","affiliation":[{"name":"Tissue Typing and Immunology of Transplants Unit, Department of Diagnostic Pathology University of Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Longhi","sequence":"additional","affiliation":[{"name":"Laboratory of Transplant Immunology IRCCS Ca ' Granda Foundation Maggiore Policlinico Hospital Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Manfroi","sequence":"additional","affiliation":[{"name":"Immunohaematology and Transfusion Medicine Service, S. 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