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Its expression has been described in various cancer types, including ovarian cancer. HLA\u2010G molecule has been implicated in immune escape and in progression of ovarian tumor cells. Our goal was to assess if total soluble (s)HLA\u2010G molecules or HLA\u2010G5 and sHLA\u2010G1 isoforms could be considered as circulating ovarian tumor biomarkers, we measured the concentration of these molecules in ovarian carcinoma patients stratified according with their clinicopathological parameters. sHLA\u2010G, sHLA\u2010G1 and HLA\u2010G5 concentrations were dosed in plasma samples by sandwich\u2010ELISA. The sHLA\u2010G dimerization was analyzed after immunoprecipitation and SDS\u2010PAGE migration. Total sHLA\u2010G and sHLA\u2010G1 levels were significantly represented in plasma of ovarian carcinoma patients compared to healthy controls. sHLA\u2010G1 isoform concentration was highly represented in ovarian carcinoma compared to HLA\u2010G5 isoforms. Additionally, high sHLA\u2010G molecules have been found in aged patients, as well as in patients with advanced stages, and those with metastatic lymph nodes and those with distant metastasis. Elsewhere, sHLA\u2010G monomers were highly represented in ovarian carcinoma patients compared to controls. sHLA\u2010G plasmatic protein was highly represented in ovarian carcinoma. In effect, HLA\u2010G might be considered as a new checkpoint molecule that could be used to assess progression and recurrence of the disease, thus placing it as a potential biomarker for advanced and complicated ovarian carcinoma.<\/jats:p>","DOI":"10.1111\/tan.14374","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T11:24:05Z","timestamp":1626521045000},"page":"357-365","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic significance of high circulating <scp>sHLA\u2010G<\/scp> in ovarian carcinoma"],"prefix":"10.1111","volume":"98","author":[{"given":"Wafa","family":"Babay","sequence":"first","affiliation":[{"name":"Laboratory Microorganismes and Active Biomolecules, Faculty of Sciences of Tunis University of Tunis El Manar  Tunis 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