{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:54:27Z","timestamp":1783464867247,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>The polymorphism of the HLA system has been extensively studied in COVID\u201019 infection, however there are no data about the role of HLA on vaccine response. We report here the HLA\u2010A, \u2010B, \u2010C, and DRB1 allelic frequencies of <jats:italic>n<\/jats:italic>\u00a0=\u2009111 individuals after BNT162b2 mRNA vaccine, selected on the basis of lower antibody levels (&lt;5% percentile) after the second dose among a total of <jats:italic>n<\/jats:italic>\u00a0=\u20092569 vaccinees, and compare them with the frequencies of a reference population. We found that differences in the frequencies of the alleles HLA\u2010A*03:01, A*33:03, B*58:01 and at least one haplotype (HLA\u2010A*24:02~C*07:01~B*18:01~DRB1*11:04) are associated with a weaker antibody response after vaccination, together with the age of vaccinees. Our results might suggest a role played by some HLA alleles or haplotypes in antibody production after the BNT162b2 mRNA vaccine, giving insights into the tracking of potentially susceptible individuals across populations. Further studies are needed to better define our exploratory findings and dissect the role of HLA polymorphism on response to anti\u2010COVID\u201019 vaccines.<\/jats:p>","DOI":"10.1111\/tan.14546","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T15:17:45Z","timestamp":1642087065000},"page":"183-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Polymorphism of the <scp>HLA<\/scp> system and weak antibody response to <scp>BNT162b2 mRNA<\/scp> vaccine"],"prefix":"10.1111","volume":"99","author":[{"given":"Roberto","family":"Crocchiolo","sequence":"first","affiliation":[{"name":"Servizio di Immunoematologia e Medicina Trasfusionale ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Gallina","sequence":"additional","affiliation":[{"name":"Italian Bone Marrow Donor Registry E. O. 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Ospedali Galliera  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Miotti","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics Santa Maria della Misericordia University Hospital  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Matteo","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Postgraduate School of Clinical Pharmacology and Toxicology Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Unit ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Vismara","sequence":"additional","affiliation":[{"name":"Chemical\u2010Clinical and Microbiological Analyses ASST Grande Ospedale Metropolitano Niguarda  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