{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:45:40Z","timestamp":1777535140829,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573206"],"award-info":[{"award-number":["81573206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019HC006"],"award-info":[{"award-number":["2019HC006"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>HLA class II molecules, HLA\u2010DR, DP and DQ, together with HLA II\u2010like protein DM, play a dominant role in the processing and presentation of antigens, which may influence vaccine effectiveness. We previously demonstrated that variations in the HLA\u2010DRB1, DPB1 and DQB1 genes may affect the neutralising antibody (NAb) response induced by the inactivated Japanese encephalitis vaccine (IJEV). In the present study, we genotyped HLA\u2010DPA1, DQA1, DMA and DMB genes and used previous HLA\u2010DRB1, DPB1 and DQB1 data to evaluate the association of these genes with IJEV\u2010induced NAbs, at both the seroconversion and geometric mean titres (GMTs). We confirmed the seropositive association of <jats:italic>DQB1*02:01<\/jats:italic> and NAbs (0.156 vs. 0.075, <jats:italic>p_adj<\/jats:italic>\u00a0=\u20090.018; OR\u00a0=\u00a02.270; 95% CI\u00a0=\u00a01.285\u20133.999) and seronegative association of <jats:italic>DQB1*02:02<\/jats:italic> (0.014 vs. 0.09, <jats:italic>p_adj<\/jats:italic>\u00a0=\u20090.0002; OR\u00a0=\u00a00.130; 95% CI\u00a0=\u00a00.047\u20130.400). Furthermore, the <jats:italic>DMB*01:03\u2013DMA*01:01\u2013DPA1*01:03\u2013DPB1*04:01<\/jats:italic> haplotype was associated with a negative response (0.020 vs. 0.074; <jats:italic>p_adj<\/jats:italic>\u00a0=\u20090.03; OR\u00a0=\u00a00.250; 95% CI\u00a0=\u00a00.097\u20130.649), whereas <jats:italic>DRB1*15:02\u2013DMB*01:01\u2013DMA*01:01<\/jats:italic> was associated with a positive response (0.034 vs. 0; <jats:italic>p_adj<\/jats:italic>\u00a0=\u20090.044). In addition, <jats:italic>DRB1*12:02<\/jats:italic>, <jats:italic>DRB1*13:02<\/jats:italic>, <jats:italic>DPB1*04:01<\/jats:italic>, <jats:italic>DPB1*05:01<\/jats:italic>, <jats:italic>DPB1*09:01<\/jats:italic>, <jats:italic>DQA1*06:01<\/jats:italic> and <jats:italic>DQA1*01:02<\/jats:italic> were associated with a higher GMT of NAbs, whereas <jats:italic>DRB1*11:01<\/jats:italic>, <jats:italic>DPB1*13:01<\/jats:italic> and <jats:italic>DQA1*05:05<\/jats:italic> were associated with a lower GMT of NAbs. In conclusion, the present study suggests that variations in the HLA\u2010DM and HLA class II genes, as well as their combined allotypes, may influence the IJEV NAbs at seroconversion and GMT levels.<\/jats:p>","DOI":"10.1111\/tan.14575","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T05:03:15Z","timestamp":1643950995000},"page":"357-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of <scp>HLA\u2010DM<\/scp> and <scp>HLA<\/scp> class <scp>II<\/scp> genes with antibody response induced by inactivated Japanese encephalitis vaccine"],"prefix":"10.1111","volume":"99","author":[{"given":"Jihong","family":"He","sequence":"first","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Kunming 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