{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:08:37Z","timestamp":1791526117840,"version":"4.3.4"},"reference-count":125,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>HLA serological specificities were defined by the reactivity of HLA molecules with sets of sera and monoclonal antibodies. Many recently identified alleles defined by molecular typing lack their serotype assignment. We surveyed the literature describing the correlation of the reactivity of serologic reagents with AA residues. 20 \u2010 25 AA residues determining epitopes (DEP) that correlated with 82 WHO\u00a0serologic specificities were identified for HLA class I loci. Thirteen DEP each located in the beta\u20101 domains that correlated with 24 WHO\u00a0serologic specificities were identified for HLA\u2010DRB1 and \u2010DQB1 loci. The designation of possible HLA\u2010DPB1, \u2010DQA1, \u2010DPA1, and additional serological specificities that result from epitopes defined by residues located at both \u2010DQA1 and \u2010DQB1 subunits were also examined. HATS software was developed for automated serotype assignments to HLA alleles in one of the three hierarchical matching criteria: (1) all DEP (FULL); (2) selected DEP specific to each serological specificity (SEROTYPE); (3) one AA mismatch with one or more SEROTYPES (INCOMPLETE). Results were validated by evaluating the alleles whose serotypes do not correspond to the first field of the allele name listed in the HLA dictionary. Additional 85 and 21 DEP patterns that do not correspond to any WHO serologic specificities for common HLA class I and DRB1 alleles were identified, respectively. A comprehensive antibody identification panel would allow for accurate unacceptable antigen listing and compatibility predictions in solid organ transplantation. We propose that antibody\u2010screening panels should include all serologic specificities identified in this study.<\/jats:p>","DOI":"10.1111\/tan.14662","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T04:23:39Z","timestamp":1652243019000},"page":"193-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A new strategy for systematically classifying <scp>HLA<\/scp> alleles into serological specificities"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-4255","authenticated-orcid":false,"given":"Kazutoyo","family":"Osoegawa","sequence":"first","affiliation":[{"name":"Histocompatibility and Immunogenetics Laboratory Stanford Blood Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-4120","authenticated-orcid":false,"given":"Steven G. 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