{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:37:05Z","timestamp":1768001825654,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Graft\u2010versus\u2010host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) and is highly influenced by the degree of HLA matching between recipient and donor. The HLA\u2010class Ib molecule HLA\u2010G has been shown to promote tolerogenicity through its interaction with inhibitory receptors found on several immunocompetent cells. We hypothesized that in an allo\u2010HSCT setting, HLA\u2010G mismatches may negatively impact the HLA\u2010G\u2010mediated tolerogenicity either due to inefficient interaction with the inhibitory receptors of the transplanted immune cells or due to direct allorecognition of mismatched HLA\u2010G on host cells by the immune cells of the donor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In order to explore this hypothesis, we investigated the impact of HLA\u2010G mismatching in 2.083 10\/10 matched high resolution HLA\u2010typed allo\u2010HSCT transplants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the risk of chronic GvHD was significantly higher in HLA\u2010G\u2010mismatched transplant cases as compared with the HLA\u2010G\u2010matched control group (HR: 1.46, 95%CI\u00a0=\u00a01.11\u20131.91, <jats:italic>p<\/jats:italic>\u00a0=\u20090.006). Sub\u2010analysis of the mismatch vector revealed that this effect was only detectable in the GvH (HR: 1.89, 95%CI 1.39\u20132.57, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but not the HvG direction (HR: 1.01, 95%CI\u00a0=\u00a00.63\u20131.63, <jats:italic>p<\/jats:italic>\u00a0=\u20090.967). In addition, the negative impact of HLA\u2010G mismatching on chronic GvHD was only significant in younger patients (&lt;30y HR: 3.02, 95%CI\u00a0=\u00a01.25\u20137.28, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014; &gt;29y HR: 1.28, 95%CI\u00a0=\u00a00.94\u20131.72, <jats:italic>p<\/jats:italic>\u00a0=\u20090.113).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our results indicate that HLA\u2010G mismatches may contribute to the onset of chronic GvHD, especially in younger patients and should therefore be avoided when possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tan.14733","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T05:28:46Z","timestamp":1657258126000},"page":"349-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Higher risk for chronic graft\u2010versus\u2010host disease (<scp>GvHD<\/scp>) in <scp>HLA\u2010G<\/scp> mismatched transplants following allogeneic hematopoietic stem cell transplantation: A retrospective study"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9935-8042","authenticated-orcid":false,"given":"Christine","family":"Neuchel","sequence":"first","affiliation":[{"name":"Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg \u2013 Hessen, Ulm University Hospital of Ulm  Ulm Germany"},{"name":"Institute of Transfusion Medicine University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sowmya","family":"Gowdavally","sequence":"additional","affiliation":[{"name":"Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg \u2013 Hessen, Ulm University Hospital of Ulm  Ulm Germany"},{"name":"Institute of Transfusion Medicine University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysanthi","family":"Tsamadou","sequence":"additional","affiliation":[{"name":"Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg \u2013 Hessen, Ulm University Hospital of Ulm  Ulm Germany"},{"name":"Institute of Transfusion Medicine University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology University of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Sala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Wagner\u2010Drouet","sequence":"additional","affiliation":[{"name":"Department of Medicine III Johannes Gutenberg\u2010University of Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Valerius","sequence":"additional","affiliation":[{"name":"Section for Stem Cell Transplantation and Immunotherapy, Department of Medicine II Christian Albrechts University  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Wulf","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Georg\u2010August\u2010University G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[{"name":"Department of Internal 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Clinic  Oldenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mareike","family":"D\u00fcrholt","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology Evangelic Clinic Essen\u2010Werden  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Oncology and Hematology Robert Bosch Hospital  Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Hertenstein","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology Klinikum Bremen\u2010Mitte  Bremen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Klein","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin Mannheim Med. 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