{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:00Z","timestamp":1787015940067,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012019","name":"Fondation du Souffle","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>\n                    Uncontrolled inflammation of the airways in chronic obstructive lung diseases leads to exacerbation, accelerated lung dysfunction and respiratory insufficiency. Among these diseases, asthma affects 358\u00a0million people worldwide. Human bronchial epithelium cells (HBEC) express both anti\u2010inflammatory and activating molecules, and their deregulated expression contribute to immune cell recruitment and activation, especially platelets (PLT) particularly involved in lung tissue inflammation in asthma context. Previous results supported that HLA\u2010G dysregulation in lung tissue is associated with immune cell activation. We investigated here HLA\u2010F expression, reported to be mobilised on immune cell surface upon activation and displaying its highest affinity for the KIR3DS1\u2010activating NK receptor. We explored\n                    <jats:italic>HLA\u2010F<\/jats:italic>\n                    transcriptional expression in HBEC; HLA\u2010F total expression in PBMC and HBEC collected from healthy individuals at rest and upon chemical activation and HLA\u2010F membrane expression in PBMC, HBEC and PLT collected from healthy individuals at rest and upon chemical activation. We compared\n                    <jats:italic>HLA\u2010F<\/jats:italic>\n                    transcriptional expression in HBEC from healthy individuals and asthmatic patients and its surface expression in HBEC and PLT from healthy individuals and asthmatic patients. Our results support that HLA\u2010F is expressed by HBEC and PLT under healthy physiological conditions and is retained in cytoplasm, barely expressed on the surface, as previously reported in immune cells. In both cell types, HLA\u2010F reaches the surface in the inflammatory asthma context whereas no effect is observed at the transcriptional level. Our study suggests that HLA\u2010F surface expression is a ubiquitous post\u2010transcriptional process in activated cells. It may be of therapeutic interest in controlling lung inflammation.\n                  <\/jats:p>","DOI":"10.1111\/tan.14782","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T05:14:43Z","timestamp":1661058883000},"page":"491-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mobilisation of\n                    <scp>HLA\u2010F<\/scp>\n                    on the surface of bronchial epithelial cells and platelets in asthmatic patients"],"prefix":"10.1111","volume":"100","author":[{"given":"Sabrina","family":"Fiouane","sequence":"first","affiliation":[{"name":"CNRS, EFS, ADES, UMR7268 Aix Marseille University  Marseille France"},{"name":"Etablissement Fran\u00e7ais du Sang PACA Corse  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Chebbo","sequence":"additional","affiliation":[{"name":"INSERM 1263, INRAE 1260, C2VN Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Beley","sequence":"additional","affiliation":[{"name":"CNRS, EFS, ADES, UMR7268 Aix Marseille University  Marseille France"},{"name":"Etablissement Fran\u00e7ais du Sang PACA Corse  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Paganini","sequence":"additional","affiliation":[{"name":"Xegen  Gemenos France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9118-5239","authenticated-orcid":false,"given":"Christophe","family":"Picard","sequence":"additional","affiliation":[{"name":"CNRS, EFS, ADES, UMR7268 Aix Marseille University  Marseille France"},{"name":"Etablissement Fran\u00e7ais du Sang PACA Corse  Marseille 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