{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:17:40Z","timestamp":1787242660873,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010731","name":"Faculty of Medicine, Chiang Mai University","doi-asserted-by":"publisher","award":["01\/2004"],"award-info":[{"award-number":["01\/2004"]}],"id":[{"id":"10.13039\/501100010731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n                    HLA studies in patients with systemic sclerosis (SSc) have shown variable results. This study aimed to examine the association of HLA class I and II risk alleles in Thai SSc patients, and clarify the contribution of risk HLA alleles to the pathogenesis and clinical manifestations. Blood samples from 92 SSc patients and 135 healthy controls (HCs) were collected. Eleven loci of the HLA class I (HLA\u2010A, B, and C) and class II (HLA\u2010DR, DP, and DQ) genes were determined by a 3\u2010field (6\u2010digit) analysis using the Next Generation DNA Sequencing (NGS) method. Anti\u2010topoisomerase\u2010I antibodies (ATA) and anti\u2010centromere antibodies (ACA) were identified by ELISA methods. Allele frequencies (AFs) of\n                    <jats:italic>HLA\u2010DRB1*15:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DRB5*01:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DQB1*05:01:24<\/jats:italic>\n                    ,\n                    <jats:italic>DPB1*13:01:01<\/jats:italic>\n                    , and\n                    <jats:italic>DQA1*01:01:01<\/jats:italic>\n                    were increased significantly in the whole SSc and SSc patients with positive ATA, but with negative ACA (SSc\/ATA+\/ACA\u2212). Of these,\n                    <jats:italic>DPB1*13:01:01<\/jats:italic>\n                    was the most susceptible allele. The\n                    <jats:italic>DRB1*15:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DQB1:05:01:24<\/jats:italic>\n                    , and\n                    <jats:italic>DPB1*13:01:01<\/jats:italic>\n                    alleles were estimated to locate on the unique haplotype, and haplotype frequency was estimated to be significantly higher than those in the HCs (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002). The linkage analysis of\n                    <jats:italic>DRB1*15\/16<\/jats:italic>\n                    revealed that most of the\n                    <jats:italic>DRB1*15:02:01<\/jats:italic>\n                    alleles were linked to\n                    <jats:italic>DRB5*01:02:01<\/jats:italic>\n                    or\n                    <jats:italic>DRB5*01:08:01N<\/jats:italic>\n                    . The linkage of\n                    <jats:italic>DRB1*16:02:01<\/jats:italic>\n                    to\n                    <jats:italic>DRB5*01:01:01<\/jats:italic>\n                    was observed frequently. The associations of risk alleles with several SSc clinical features were observed.\n                    <jats:italic>HLA\u2010DRB1*15:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DRB5*01:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DQB1*05:01:24<\/jats:italic>\n                    , and\n                    <jats:italic>DPB1*13:01:01<\/jats:italic>\n                    on the unique haplotype were associated with the pathogenesis and clinical features of SSc in Thai patients. The linkage of\n                    <jats:italic>DRB1*15:02:01<\/jats:italic>\n                    to\n                    <jats:italic>DRB5*01:08:01N<\/jats:italic>\n                    was observed commonly in northern Thai patients.\n                  <\/jats:p>","DOI":"10.1111\/tan.14793","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T22:13:41Z","timestamp":1661811221000},"page":"563-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of\n                    <i>HLA\u2010DRB1*15:02:01<\/i>\n                    ,\n                    <i>DQB1*05:01:24<\/i>\n                    and\n                    <i>DPB1*13:01:01<\/i>\n                    in Thai patients with systemic sclerosis"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-6122","authenticated-orcid":false,"given":"Worawit","family":"Louthrenoo","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuntana","family":"Kasitanon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antika","family":"Wongthanee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Okudaira","sequence":"additional","affiliation":[{"name":"GenoDive Pharma Inc.  Naka\u2010cho Honatugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Graduate School of Human Development and Environment Kobe University  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-7087","authenticated-orcid":false,"given":"Fumiaki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"GenoDive Pharma Inc.  Naka\u2010cho Honatugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Habata","sequence":"additional","affiliation":[{"name":"GenoDive Pharma Inc.  Naka\u2010cho Honatugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anri","family":"Masuya","sequence":"additional","affiliation":[{"name":"GenoDive Pharma Inc.  Naka\u2010cho Honatugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Noguchi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences University of Shizuoka  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Inoko","sequence":"additional","affiliation":[{"name":"GenoDive Pharma Inc.  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