{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:45:39Z","timestamp":1761677139625,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Between January 2018 and June 2021, the Ezer Mizion recruited 223,960 donors. All donors were typed for their HLA class I and II alleles at high resolution by Next Generation Sequencing techniques. Comparison between the sequences obtained from these donors and those in the IPD\u2010IMGT\/HLA Database, revealed 122 Novel HLA alleles that were found in 133 donors. Most of the alleles, 94 (77%) were identified in the HLA class I genes (30, 35, and 29 in HLA\u2010A, \u2010B, and \u2013C, respectively), and 28 (23%) were detected in the HLA class II genes (9 in HLA\u2010DRB1 and \u2010DQB1 and 10 in \u2010DPB1). Most of these novel alleles, 106 (86.9%) comprised single nucleotide variation (SNV), 9 (7.4%) present multiple amino acids variation, 4 and 3 were generated because of deletions and insertions, respectively. Ten of these novel alleles were seen to be null alleles.<\/jats:p>","DOI":"10.1111\/tan.14933","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T17:04:07Z","timestamp":1670519047000},"page":"507-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification and characterization of 122 novel <scp>HLA<\/scp> alleles in bone marrow donors recruited to the Ezer Mizion Bone Marrow Donor Registry"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-7810","authenticated-orcid":false,"given":"Amal","family":"Bishara","sequence":"first","affiliation":[{"name":"Friends To Marrow  Arara Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigal","family":"Manor","sequence":"additional","affiliation":[{"name":"Ezer Mizion Bone Marrow Donor Registry  Petach\u2010Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Tanous","sequence":"additional","affiliation":[{"name":"Friends To Marrow  Arara Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehudit","family":"Eitiel","sequence":"additional","affiliation":[{"name":"Ezer Mizion Bone Marrow Donor Registry  Petach\u2010Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nezih","family":"Cereb","sequence":"additional","affiliation":[{"name":"Histogenetics  Ossining New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bracha","family":"Zisser","sequence":"additional","affiliation":[{"name":"Ezer Mizion Bone Marrow Donor Registry  Petach\u2010Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.09.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.09.015"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2015.08.002"},{"key":"e_1_2_5_5_1","first-page":"948","article-title":"IPD\u2010IMGT\/HLA database","volume":"48","author":"Robinson J","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12304"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13764"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018028662"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.14933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.14933","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.14933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T06:28:57Z","timestamp":1692426537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.14933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/tan.14933"],"URL":"https:\/\/doi.org\/10.1111\/tan.14933","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"type":"print","value":"2059-2302"},{"type":"electronic","value":"2059-2310"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"2022-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}