{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:51:07Z","timestamp":1786967467815,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    Antibodies against human neutrophil antigens (HNAs) play a significant role in various clinical conditions such as neonatal alloimmune neutropenia, transfusion\u2010related acute lung injury, and other nonhemolytic transfusion reactions. This study aims to identify the genotype and allele frequencies of HNAs in the healthy Indian population. Ten genetic variants in four human genes encoding alleles of HNAs class I\u2013V approved by the International Society of Blood Transfusion\u2014Granulocyte Immunobiology Working Party were used in the analysis. Genetic variants from whole genome sequences of 1029 healthy Indian individuals corresponding to HNA alleles were analyzed. The frequencies of the variants were compared with global population datasets using an in\u2010house computational pipeline. In HNA class I, allele frequencies of\n                    <jats:italic>FCGR3B*01<\/jats:italic>\n                    ,\n                    <jats:italic>FCGR3B*02<\/jats:italic>\n                    , and\n                    <jats:italic>FCGR3B*03<\/jats:italic>\n                    encoding HNA\u20101a, HNA\u20101b, and HNA\u20101c were 0.07, 0.8, and 0.13, respectively. HNA class 3 alleles namely\n                    <jats:italic>SLC44A2*01<\/jats:italic>\n                    (encoding HNA\u20103a) and\n                    <jats:italic>SLC44A2*02<\/jats:italic>\n                    (encoding HNA\u20103b) were found at allele frequencies of 0.78 and 0.22, respectively. The frequencies of\n                    <jats:italic>ITGAM*01<\/jats:italic>\n                    encoding HNA\u20104a and\n                    <jats:italic>ITGAM*02<\/jats:italic>\n                    encoding HNA\u20104a were 0.95 and 0.05, respectively. Furthermore, allele frequencies of HNA class 5 alleles were 0.32 for\n                    <jats:italic>ITGAL*01<\/jats:italic>\n                    (encoding HNA\u20105a) and 0.68 for\n                    <jats:italic>ITGAL*02<\/jats:italic>\n                    (encoding HNA\u20105b). Interestingly, it was also found that rs2230433 variant deciding the HNA class 5 alleles, was highly prevalent (78.2%) in the Indian population compared with other global populations. This study presents the first comprehensive report of HNA allele and genotype frequencies in the Indian population using population genome datasets of 1029 individuals. Significant difference was observed in the prevalence of HNA5a and HNA5b in India in comparison to other global populations.\n                  <\/jats:p>","DOI":"10.1111\/tan.14938","type":"journal-article","created":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T07:23:30Z","timestamp":1670743410000},"page":"262-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic landscape of human neutrophil antigen variants in India from population\u2010scale genomes"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-9112","authenticated-orcid":false,"given":"Mercy","family":"Rophina","sequence":"first","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul C.","family":"Bhoyar","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Imran","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vigneshwar","family":"Senthivel","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit Kumar","family":"Divakar","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and 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