{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:34:46Z","timestamp":1791063286545,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Immune\u2010mediated necrotizing myopathy (IMNM) is a type of autoimmune myositis typically characterized clinically by proximal muscle weakness with elevated creatine kinase levels, pathologically by myofiber necrosis and regeneration with paucity of lymphocytic cell infiltration, and serologically by the presence of either of two myositis\u2010specific autoantibodies, anti\u2010SRP, and anti\u2010HMGCR antibodies. However, the HLA loci and alleles associated with IMNM are still not fully understood at least partly because IMNM was a relatively recently established condition. In this study, we genotyped the six HLA loci (HLA\u2010A, \u2010B, \u2010C, \u2010DRB1, \u2010DQB1 and \u2010DPB1) in 250 patients (237 patients over age 18\u2009years and 13 juvenile patients) diagnosed with IMNM based on clinicopathological features and autoantibody information and performed a case control study with Japanese healthy subjects. In the adult patients, specific HLA alleles associated with IMNM were identified at all HLA loci, with<jats:italic>DRB1*08:03<\/jats:italic>showing the strongest association (OR\u00a0=\u00a02.5;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.00000017). Furthermore, subgroup analysis with various clinical information showed that<jats:italic>C*03:04<\/jats:italic>(OR\u00a0=\u00a03.7;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.00012) was a higher risk allele for collagen disease in adult patients, and<jats:italic>B*13:01<\/jats:italic>(OR\u00a0=\u00a023.2;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) and<jats:italic>C*03:04<\/jats:italic>(OR\u00a0=\u00a05.8;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0074) were higher risk for juvenile patients with anti\u2010HMGCR antibody\u2010positive IMNM. These findings will help to better understand the HLA genetic background and features of IMNM in designing future studies.<\/jats:p>","DOI":"10.1111\/tan.14950","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T07:59:05Z","timestamp":1671868745000},"page":"449-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association of immune\u2010mediated necrotizing myopathy with<scp>HLA<\/scp>polymorphisms"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-6485","authenticated-orcid":false,"given":"Yuko","family":"Ohnuki","sequence":"first","affiliation":[{"name":"Department of Medical Ethics Tokai University School of Medicine Kanagawa Japan"},{"name":"Department of Clinical Genetics Tokai University Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4388-4574","authenticated-orcid":false,"given":"Shigeaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4758-183X","authenticated-orcid":false,"given":"Akinori","family":"Uruha","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research, National Institute of Neuroscience, and Department of Genome Medicine Development Medical Genome Center, National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munenori","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Neurology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-582X","authenticated-orcid":false,"given":"Shingo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Molecular Life Science Tokai University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-245X","authenticated-orcid":false,"given":"Jerzy K.","family":"Kulski","sequence":"additional","affiliation":[{"name":"Department of Molecular Life Science Tokai University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9452-112X","authenticated-orcid":false,"given":"Ichizo","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research, National Institute of Neuroscience, and Department of Genome Medicine Development Medical Genome Center, National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-6708","authenticated-orcid":false,"given":"Takashi","family":"Shiina","sequence":"additional","affiliation":[{"name":"Department of Molecular Life Science Tokai University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.05.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000740"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24566"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000855"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Autoimmune myositis\u2010mechanism and therapy development","volume":"00","author":"Uruha A","year":"2021","journal-title":"Neurol Clin Neurosci"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.02.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew386"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003160"},{"issue":"8","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/acr.21671","article-title":"Increased frequency of DRB1*11:01 in anti\u2010hydroxymethylglutaryl\u2010coenzyme a reductase\u2010associated autoimmune myopathy","volume":"64","author":"Mammen AL","year":"2012","journal-title":"Arthritis Care Res"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24541"},{"key":"e_1_2_8_12_1","unstructured":"Allele frequency net database. Accessed July 20 2022.www.allelefrequencies.net\/hla.asp"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.07.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313166"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.1728"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1506827"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(92)90056-S"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2012.01941.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1990.tb01821.x"},{"key":"e_1_2_8_21_1","unstructured":"The comprehensive R archive network. Accessed March 17 2022.https:\/\/cran.r-project.org\/index.html"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-011-0521-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2015.28"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208119"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2017.01.006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2014.12.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.2598"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010022"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.14950","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.14950","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.14950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T13:46:25Z","timestamp":1701611185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.14950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,15]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/tan.14950"],"URL":"https:\/\/doi.org\/10.1111\/tan.14950","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,15]]},"assertion":[{"value":"2022-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}