{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:13:05Z","timestamp":1790745185624,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>In this observational case\u2013control study, 107 cutaneous adverse reaction (CAR) cases (CAR+) manifesting up to 12\u2009weeks after the start of treatment with antiseizure medication (ASM) were identified. Control groups consisted of 98 epilepsy patients without a history of CAR (CAR\u2010) and 3965 healthy individuals in the Brazilian National Registry of Bone Marrow Donors. All participants were HLA typed by high\u2010resolution Next Generation Sequencing for <jats:italic>HLA\u2010A, B, C, DQB1<\/jats:italic> and <jats:italic>DRB1<\/jats:italic>; <jats:italic>HLA\u2010DPA1, DPB1, DQA1, DRB3, DRB4<\/jats:italic> and <jats:italic>DRB5<\/jats:italic> were also sequenced in samples from CAR+ and CAR\u2010 individuals. The relationship between the carrier frequency of each allele, CAR type and ASM for all participants was investigated. The ASMs most frequently associated with CAR were carbamazepine (48% of CAR+ subjects), lamotrigine (23%), phenytoin (18%), phenobarbital (13%) and oxcarbazepine (5%). The main alleles associated with a risk of CAR were <jats:italic>HLA\u2010A*02:05<\/jats:italic> (OR\u2009=\u20096.28; <jats:italic>p<\/jats:italic>\u2009=\u20090.019, carbamazepine or oxcarbazepine); <jats:italic>HLA\u2010DPA1*02:02<\/jats:italic> (OR\u2009=\u20094.16, <jats:italic>p<\/jats:italic>\u2009=\u20090.003, carbamazepine); <jats:italic>HLA\u2010B*53:01<\/jats:italic> (OR\u2009=\u200947.9, <jats:italic>p<\/jats:italic>\u2009=\u20090.014, oxcarbazepine), <jats:italic>HLA\u2010DPA1*03:01\/DPB1*105:01<\/jats:italic> (OR\u2009=\u200925.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.005, phenobarbital); <jats:italic>HLA\u2010C*02:10<\/jats:italic> (OR\u2009=\u200925.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.005, phenobarbital) and <jats:italic>HLA\u2010DRB1*04:02<\/jats:italic> (OR\u2009=\u200917.22, <jats:italic>p<\/jats:italic>\u2009=\u20090.007, phenytoin). <jats:italic>HLA\u2010A*03:01<\/jats:italic> increased the risk for phenytoin\u2010induced maculopapular exanthema 4.71\u2010fold (<jats:italic>p<\/jats:italic>\u2009=\u20090.009), and <jats:italic>HLA\u2010B*35:02<\/jats:italic> was associated with a 25.6\u2010fold increase in the risk of carbamazepine\u2010induced Stevens\u2010Johnson syndrome (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). None of the 4170 subjects carried the <jats:italic>HLA\u2010B*15:02<\/jats:italic> allele, and <jats:italic>HLA\u2010A*31:01<\/jats:italic> was not associated with CAR. Hence, <jats:italic>HLA\u2010A*31:01<\/jats:italic> and <jats:italic>HLA\u2010B*15:02<\/jats:italic> were not associated with CAR in this population. Although other HLA class I and II alleles tested were associated with a risk of CAR, none of these associations were strong enough to warrant HLA testing before prescribing ASM.<\/jats:p>","DOI":"10.1111\/tan.15045","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T05:40:43Z","timestamp":1680327643000},"page":"269-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>HLA<\/scp> alleles and antiseizure medication\u2010induced cutaneous reactions in Brazil: A case\u2010control study"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-2452","authenticated-orcid":false,"given":"Tallulah","family":"Spina Tensini","sequence":"first","affiliation":[{"name":"Neurology Department Federal University of Paran\u00e1  Curitiba 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