{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:45:21Z","timestamp":1753879521979,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Recent studies showed that ABO\u2010adjusted calculated panel reactive antibody (ABO\u2010cPRA) may better reflect the histocompatibility level in a multi\u2010ethnic population, but such data in Asians is not available. We developed an ABO\u2010adjusted cPRA metric on a cohort of waitlist kidney transplant patients (<jats:italic>n<\/jats:italic>\u2009=\u2009647, 99% Chinese) in Hong Kong, based on HLA alleles and ABO frequencies of local donors. The concordance between the web\u2010based ABO\u2010cPRA calculator and the impact on kidney allocation were evaluated. The blood group distribution for A, B, O and AB among waitlist kidney candidates were 26.2%, 27.5%, 40.1%, and 6.1%, and their chances of encountering incompatible blood group donors were 32.6%, 32.4%, 57.6%, and 0%, respectively. There is poor agreement between web\u2010based ABO\u2010cPRA calculator and our locally developed metrics. Over 90% of patients showed an increase in cPRA after ABO adjustment, most notably in those with cPRA between 70% and 79%. Blood group O patients had a much greater increase in cPRA scores after adjustment while patients of blood group A and B had similar increment. 10.6% of non\u2010AB blood group waitlist patients had ABO\u2010cPRA elevated to \u226580%. A local ABO\u2010adjusted cPRA metric is required for Asian populations and may improve equity in kidney distribution for patients with disadvantageous blood groups. The result from the current study potentially helps other countries\/localities in establishing their own unified ABO\u2010cPRA metrics and predict the impact on kidney allocation.<\/jats:p>","DOI":"10.1111\/tan.15229","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T11:26:01Z","timestamp":1695209161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ABO<\/scp>\u2010adjusted <scp>cPRA<\/scp> metric for kidney allocation in an Asian\u2010predominant population"],"prefix":"10.1111","volume":"103","author":[{"given":"Kei Man","family":"Lau","sequence":"first","affiliation":[{"name":"Division of Transplantation &amp; Immunogenetics, Department of Pathology Queen Mary Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick W. 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