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In this study we retrospectively collected data from a multicenter study to analyze the distribution and impact of the pre\u2010existing anti\u2010HLA Abs in ISD\u2010HSCT. Among 402 recipients, 111 were positive for anti\u2010HLA Abs. Gender, time from diagnosis to transplantation and distribution of primary disease might be risk factors for the occurrence of anti\u2010HLA Abs. We found that patients with anti\u2010HLA Abs had delayed neutrophil engraftment and were more vulnerable to experience Cytomegalovirus (CMV) reactivation. The presence of anti\u2010HLA Abs was proved to be an independent risk factor for neutrophil engraftment (HR 1.42 95% CI 1.13\u20131.80, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and CMV reactivation (HR 2.03 95% CI 1.19\u20133.46, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). We found that anti\u2010HLA Abs have a negative impact on the prognosis in the early period after transplantation from sibling donors and anti\u2010HLA Abs was also an independent risk factor for the overall survival (OS) at 180\u2009days (HR 2.32, 95% CI 1.03\u20135.27, <jats:italic>p<\/jats:italic>\u2009=\u20090.042) among female recipients. In conclusion, anti\u2010HLA Abs have a negative impact on the prognosis early after ISD\u2010HSCT.<\/jats:p>","DOI":"10.1111\/tan.15286","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T09:55:53Z","timestamp":1701251753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of pre\u2010transplant <scp>anti\u2010HLA<\/scp> antibodies in transplants from <scp>HLA<\/scp>\u2010identical sibling donors: A multicenter study"],"prefix":"10.1111","volume":"103","author":[{"given":"Xiya","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology Soochow University  Suzhou 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