{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:42:41Z","timestamp":1790775761884,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Few data exist on the role of genetic factors involving the HLA system on response to Covid\u201019 vaccines. Moving from suggestions of a previous study investigating the association of some HLA alleles with humoral response to BNT162b2, we here compared the HLA allele frequencies among weak (<jats:italic>n<\/jats:italic>\u2009=\u2009111) and strong (<jats:italic>n<\/jats:italic>\u2009=\u2009123) responders, defined as those healthcare workers with the lowest and the highest anti\u2010Spike antibody levels after vaccination. Individuals with clinical history of Covid\u201019 or positive anti\u2010nucleocapside antibodies were excluded. We found the common <jats:italic>HLA\u2010A*03:01<\/jats:italic> allele as an independent predictor of strong humoral response (OR\u2009=\u200912.46, 95% CI: 4.41\u201335.21, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), together with younger age of vaccines (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). Correlation between antibody levels and protection from breakthrough infection has been observed, with a 2\u2010year cumulative incidence of 42% and 63% among strong and weak responders, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Due to the high frequency of <jats:italic>HLA\u2010A*03:01<\/jats:italic> and the need for seasonal vaccinations against SARS\u2010CoV\u20102 mutants, our findings provide useful information about the inter\u2010individual differences observed in humoral response after Covid\u201019 vaccine and might support further studies on the next seasonal vaccines.<\/jats:p>","DOI":"10.1111\/tan.15421","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T09:31:59Z","timestamp":1709544719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Strong humoral response after Covid\u201019 vaccination correlates with the common <scp>HLA<\/scp> allele <i>A*03:01<\/i> and protection from breakthrough infection"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-202X","authenticated-orcid":false,"given":"Roberto","family":"Crocchiolo","sequence":"first","affiliation":[{"name":"Dipartimento dei Servizi ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Frassati","sequence":"additional","affiliation":[{"name":"Etablissement Francais du Sang  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Gallina","sequence":"additional","affiliation":[{"name":"Italian Bone Marrow Donor Registry E.O. Ospedali Galliera Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Pedini","sequence":"additional","affiliation":[{"name":"Etablissement Francais du Sang  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Maioli","sequence":"additional","affiliation":[{"name":"Etablissement Francais du Sang  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Veronese","sequence":"additional","affiliation":[{"name":"Dipartimento dei Servizi ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Pani","sequence":"additional","affiliation":[{"name":"Dipartimento dei Servizi ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Scaglione","sequence":"additional","affiliation":[{"name":"Dipartimento dei Servizi ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Dipartimento dei Servizi ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Crucitti","sequence":"additional","affiliation":[{"name":"Hematology Department Azienda Sanitaria Provinciale di Trapani  Castelvetrano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-401X","authenticated-orcid":false,"given":"Nicoletta","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Italian Bone Marrow Donor Registry E.O. 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