{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:39:18Z","timestamp":1787495958087,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>We report data on six kidney or heart recipients who were administered daratumumab to treat or prevent antibody\u2010mediated rejection (ABMR). To date, data are scarce concerning the use of daratumumab in solid organ transplantation and most reports show a decrease in donor\u2010specific antigen (DSA) levels and an improvement in ABMR using a multiple myeloma daratumumab administration scheme, that is, with sequential systematic administration. Here, we report on the efficacy of daratumumab 1\/ in reducing the histological signs of ABMR, 2\/ in reducing the ability of DSA to bind to donor cells in vitro through negativation of flow cytometry crossmatching, 3\/ in preferentially being directed towards antibodies sharing epitopes, suggesting that daratumumab may specifically target activated plasma cells, 4\/ and when administered as a single dose. This last point suggests, for the first time, that, as for rituximab in auto\u2010immune diseases, the scheme for daratumumab administration could be different for targeting DSA\u2010producing plasma cells than for tumour cells.<\/jats:p>","DOI":"10.1111\/tan.15458","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:18:00Z","timestamp":1712729880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Daratumumab treatment in six highly sensitised solid organ transplant recipients: A case series and literature review"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-1628","authenticated-orcid":false,"given":"Richard","family":"Lemal","sequence":"first","affiliation":[{"name":"Service d'Histocompatibilit\u00e9 et Immunog\u00e9n\u00e9tique Centre Hospitalo\u2010Universitaire de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"},{"name":"EA 7453 CHELTER Universit\u00e9 Clermont Auvergne UCA  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Blandin","sequence":"additional","affiliation":[{"name":"Service d'Histocompatibilit\u00e9 et Immunog\u00e9n\u00e9tique Centre Hospitalo\u2010Universitaire de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Uro\u2010Coste","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie Centre Hospitalo\u2010Universitaire de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Philipponnet","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie Centre Hospitalo\u2010Universitaire de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Geoffroy","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalo\u2010Universitaire de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Elisabeth","family":"Heng","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie Centre Hospitalo\u2010Universitaire de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Garrouste","sequence":"additional","affiliation":[{"name":"EA 7453 CHELTER Universit\u00e9 Clermont Auvergne UCA  Clermont\u2010Ferrand France"},{"name":"Service de N\u00e9phrologie Centre Hospitalo\u2010Universitaire de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-4378","authenticated-orcid":false,"given":"Paul","family":"Rouzaire","sequence":"additional","affiliation":[{"name":"Service d'Histocompatibilit\u00e9 et Immunog\u00e9n\u00e9tique Centre Hospitalo\u2010Universitaire de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"},{"name":"EA 7453 CHELTER Universit\u00e9 Clermont Auvergne UCA  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1802677"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14584"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003095"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.694763"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201012\u2010687749"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201006\u2010740944"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220201"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201006\u2010275610"},{"key":"e_1_2_7_10_1","unstructured":"Eurotransplant Reference Laboratory.Virtual PRA calculator. 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