{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:54:54Z","timestamp":1781013294538,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) is the only curative therapy for adult T\u2010cell leukaemia\/lymphoma (ATL). Specific HLAs are associated with outcomes of immunotherapy and allo\u2010HSCT. We hypothesised that individual HLAs would affect the clinical outcomes of ATL patients after allo\u2010HSCT. Using data from a Japanese registry, we retrospectively analysed 829 patients with ATL who received transplants from HLA\u2010identical sibling donors or HLA\u2010A, \u2010B, \u2010C or \u2010DRB1 allele\u2010matched unrelated donors between 1996 and 2015. We evaluated the overall mortality risk of HLA\u2010A, \u2010B and \u2010DR antigens with frequencies exceeding 3%. Outcomes were compared between transplants with or without specific HLA antigens. Of the 25 HLAs, two candidates were identified but showed no statistically significant differences by multiple comparison. HLA\u2010B62 was associated with a lower risk of mortality (hazard ratio [HR], 0.68; 95% confidence interval [CI]: 0.51\u20130.90; <jats:italic>p<\/jats:italic>\u2009=\u20090.008), whereas HLA\u2010B60 was associated with a higher risk of mortality (HR, 1.64; 95% CI: 1.19\u20132.27; <jats:italic>p<\/jats:italic>\u2009=\u20090.003). In addition, HLA\u2010B62 was associated with a lower risk of transplant\u2010related mortality (TRM) (HR, 0.52; 95% CI: 0.32\u20130.85, <jats:italic>p<\/jats:italic>\u2009=\u20090.009), whereas HLA\u2010B60 was associated with a higher risk of grades III\u2013IV acute graft\u2010versus\u2010host disease (HR, 2.63; 95% CI: 1.62\u20134.27; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Neither HLA influenced relapse. The higher risk of acute GVHD in HLA\u2010B60\u2010positive patients and the lower risk of TRM in HLA\u2010B62\u2010positive patients were consistent with previously obtained results from patients with other haematological malignancies. Consideration of HLA in ATL patients may help to predict risk and outcomes after allo\u2010HSCT.<\/jats:p>","DOI":"10.1111\/tan.15555","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T06:57:27Z","timestamp":1718693847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Individual <scp>HLAs<\/scp> affect survival after allogeneic stem cell transplantation in adult T\u2010cell leukaemia\/lymphoma"],"prefix":"10.1111","volume":"103","author":[{"given":"Satoko","family":"Morishima","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, (Second Department of Internal Medicine), Graduate School of Medicine University of the Ryukyus  Nishihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yoshimitsu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology Kagoshima University Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takero","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine, Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura General Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Immunology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumu","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura General Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Department of Hematology National Hospital Organization Kumamoto Medical Center  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Hematology Hamanomachi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youko","family":"Suehiro","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy National Hospital Organization Kyushu Cancer Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Itonaga","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Unit Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Hematology Oita Prefectural Hospital  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine, Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Hematology Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Sawayama","sequence":"additional","affiliation":[{"name":"Department of Hematology Sasebo City General Hospital  Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhei","family":"Tomori","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, (Second Department of Internal Medicine), Graduate School of Medicine University of the Ryukyus  Nishihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Atsuta","sequence":"additional","affiliation":[{"name":"Japanese Data Center for Hematopoietic Cell Transplantation  Nagoya Japan"},{"name":"Department of Registry Science for Transplant and Cellular Therapy Aichi Medical University School of Medicine  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ATL Working Group of the Japanese Society for Transplantation and Cellular 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