{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:12:51Z","timestamp":1782832371875,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF\u20102018\u201012367807"],"award-info":[{"award-number":["RF\u20102018\u201012367807"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin\u2010associated BP (GABP) patients. A significant association between <jats:italic>HLA\u2010DQB1*03:01<\/jats:italic> allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: <jats:italic>DRB1*11:01<\/jats:italic>, <jats:italic>DRB3*02:02<\/jats:italic>, <jats:italic>DQA1*05:05<\/jats:italic>, <jats:italic>DQB1*03:01<\/jats:italic> or <jats:italic>DRB1*11:04<\/jats:italic>, <jats:italic>DRB3*02:02<\/jats:italic>, <jats:italic>DQA1*05:05<\/jats:italic> and <jats:italic>DQB1*03:01<\/jats:italic>. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.<\/jats:p>","DOI":"10.1111\/tan.15616","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T08:19:45Z","timestamp":1722586785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>HLA<\/scp> alleles associated to susceptibility to gliptin\u2010associated bullous pemphigoid in Italian patients"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-3624","authenticated-orcid":false,"given":"Marco","family":"Andreani","sequence":"first","affiliation":[{"name":"Laboratorio di Immunogenetica dei Trapianti IRCCS Ospedale Pediatrico Bambino Ges\u00f9  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feliciana","family":"Mariotti","sequence":"additional","affiliation":[{"name":"Molecular and Cell Biology Laboratory Istituto Dermopatico dell'Immacolata (IDI)\u2010IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pira","sequence":"additional","affiliation":[{"name":"Molecular and Cell Biology Laboratory Istituto Dermopatico dell'Immacolata (IDI)\u2010IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Dipartimento di Onco\u2010Ematologia e Terapia Cellulare e Genica IRCCS Ospedale Pediatrico Bambino Ges\u00f9  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Testa","sequence":"additional","affiliation":[{"name":"Laboratorio di Immunogenetica dei Trapianti IRCCS Ospedale Pediatrico Bambino Ges\u00f9  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-2383","authenticated-orcid":false,"given":"Mariarosa","family":"Battarra","sequence":"additional","affiliation":[{"name":"Laboratorio di Immunogenetica dei Trapianti IRCCS Ospedale Pediatrico Bambino Ges\u00f9  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Caputi","sequence":"additional","affiliation":[{"name":"Molecular and Cell Biology Laboratory Istituto Dermopatico dell'Immacolata (IDI)\u2010IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Scarabello","sequence":"additional","affiliation":[{"name":"Dermatology Unit National Institute for Infectious Diseases IRCCS \u2010 L. Spallanzani  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-5500","authenticated-orcid":false,"given":"Barbara","family":"Bellei","sequence":"additional","affiliation":[{"name":"Laboratory of Cutaneous Physiopathology and Integrated Center for Metabolomics Research San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Di Campli","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Limb Salvage and Diabetic Foot, IDI\u2010IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Collina","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Limb Salvage and Diabetic Foot, IDI\u2010IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Esposito","sequence":"additional","affiliation":[{"name":"Institute of Dermatology Fondazione Policlinico Universitario A. 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