{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:00:49Z","timestamp":1784127649135,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>HLA donor specific antibodies (DSA) are implicated in antibody\u2010mediated rejection (AMR), graft dysfunction and failure in kidney transplant (KT) recipients. Non\u2010HLA antibodies including angiotensin II type 1 receptor (AT1R) may also play a role in AMR, impact graft function and survival. Data is limited in paediatric KT cohorts. We aimed to assess the prevalence and effect of pre\u2010transplant AT1R antibodies on rejection, graft function and survival in paediatric KT recipients. This was a retrospective cohort study conducted across two paediatric centres including KT recipients with a pre\u2010transplant AT1R antibody level. Outcomes included rejection, de novo DSA formation, graft function, failure, proteinuria and hypertension. Of 71 individuals, 72% recorded a positive pre\u2010transplant AT1R Ab level (\u226517\u2009U\/mL). Over a median follow\u2010up of 4.7\u2009years, AT1R Ab positivity demonstrated a trend towards increased risk of rejection however was not statistically significant (HR 3.45, 95% CI 0.97\u201312.35, <jats:italic>p<\/jats:italic>\u2010value 0.06). Sensitivity analysis with AT1R Ab levels of \u226525\u2009U\/mL (HR 2.05 95% CI 0.78\u20135.39, <jats:italic>p<\/jats:italic>\u2010value 0.14) and \u226540\u2009U\/mL (HR 1.32, CI 95% 0.55\u20133.17, <jats:italic>p<\/jats:italic>\u2010value 0.53) validated this. De novo DSA formation occurred more frequently with AT1R Ab positivity (41% vs. 20%, <jats:italic>p<\/jats:italic>\u2010value 0.9). AT1R Ab was not associated with hypertension, proteinuria, graft failure or dysfunction. In conclusion, this cohort study demonstrated a high prevalence of pre\u2010transplant AT1R Ab positivity (72%). AT1R Ab positivity demonstrated a trend towards increased risk of rejection and de novo DSA formation however did not meet statistical significance. There was no association between AT1R Ab and hypertension, proteinuria, graft failure or dysfunction.<\/jats:p>","DOI":"10.1111\/tan.15649","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T09:19:02Z","timestamp":1725873542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of angiotensin <scp>II<\/scp> type 1 receptor antibodies on graft function and survival in paediatric kidney transplant recipients"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-9677","authenticated-orcid":false,"given":"R. F.","family":"Kermond","sequence":"first","affiliation":[{"name":"Department of Paediatric Nephrology Women's and Children's Hospital  Adelaide Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Kensington Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology The Children's Hospital Westmead  Sydney Australia"},{"name":"Centre for Kidney research Children's Hospital Westmead  Sydney Australia"},{"name":"School of Public Health Sydney University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mackie","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales  Kensington Australia"},{"name":"Department of Paediatric Nephrology Sydney Children's Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology The Children's Hospital Westmead  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P.","family":"Carroll","sequence":"additional","affiliation":[{"name":"South Australian Transplantation Immunogenetic Laboratory, Australian Red Cross Lifeblood  Adelaide Australia"},{"name":"Department of Health Sciences University of South Australia  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Nephrology Westmead Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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