{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:43:34Z","timestamp":1790757814321,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Eplet 52SK is unique in the HLA eplet registry as targeting the whole family of <jats:italic>DQA1*01<\/jats:italic> alleles. It is proposed as an antibody\u2010verified eplet but has not been validated enough to deserve this label. Especially, confusion can occur with reactivity targeting the 52PQ eplet which is present on the <jats:italic>DQB1*05<\/jats:italic> and <jats:italic>DQB1*06<\/jats:italic> alleles families, as DQ molecule stability imposes <jats:italic>DQA1*01<\/jats:italic> to selectively associate with these DQ\u2010\u03b2 families only. Using two Luminex single antigen (LSA) assays from two vendors, beads bearing DR\u2010\u03b1\/DQ6 heterodimers, a special build LSA panel of additional DQ beads, and an adsorption\/elution strategy relying on cells from deceased donors or recombinant cells solely expressing one DQ antigen, we definitely established the antibody\u2010verified status of eplet 52SK using patients' sera reacting only against the DQ5 and DQ6 beads of the One Lambda LSA panel in routine patients' follow up. We also show that reactivity against this eplet is not a rare event among anti\u2010DQ1 immunisation. This study further strengthens the importance of considering the DQA1 locus in immunological studies of HLA and in organ allocation strategies.<\/jats:p>","DOI":"10.1111\/tan.15700","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T13:25:36Z","timestamp":1727789136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterisation of the <scp>HLA<\/scp>\u2010<scp>DQ<\/scp> alpha eplet <scp>52SK<\/scp> targeting the <scp><i>DQA1*01<\/i><\/scp> alleles family"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-4677","authenticated-orcid":false,"given":"Magali","family":"Devriese","sequence":"first","affiliation":[{"name":"Department of Immunology and Histocompatibility, Saint Louis Hospital  Paris France"},{"name":"Research Department of St Louis INSERM UMR976, University Paris Cite  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-4276","authenticated-orcid":false,"given":"Jar How","family":"Lee","sequence":"additional","affiliation":[{"name":"Terasaki Innovation Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3768-8756","authenticated-orcid":false,"given":"Tina","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Research and Development One Lambda, Inc. 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