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We compared characteristics of type 1 diabetes among 5530 Finnish children aged 0\u201314\u2009years diagnosed between 2003 and 2018. Seventy\u2010five children with type 1 diabetes carried the <jats:italic>DQB1*06:02<\/jats:italic> allele. The carriers of <jats:italic>DQB1*06:02<\/jats:italic> allele were compared to all children with type 1 diabetes without this allele and those with a high\u2010risk genotype. We also analysed, how does the genotype of a high\u2010risk haplotype paired with <jats:italic>DQB1*06:02<\/jats:italic> affect the phenotype of patients with newly diagnosed type 1 diabetes. Carriers of the <jats:italic>DQB1*06:02<\/jats:italic> allele were diagnosed at an older age than those with any other HLA class II genotype (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) or the high\u2010risk genotype (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After adjusting the results for age and sex, no significant differences in clinical markers were observed. Glutamic acid decarboxylase autoantibody (GADA) levels were higher among carriers of <jats:italic>DQB1*06:02<\/jats:italic> when compared to those with other genotypes (<jats:italic>p<\/jats:italic>\u2009=\u20090.033). Having a high\u2010risk haplotype paired with <jats:italic>DQB1*06:02<\/jats:italic>\u2010positive haplotype was associated with higher levels of islet antigen 2 autoantibodies (IA\u20102A) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and somewhat shorter duration of symptoms (<jats:italic>p<\/jats:italic>\u2009=\u20090.043). The association between the protective <jats:italic>DQB1*06:02<\/jats:italic> allele and an older age at diagnosis as well as higher levels of GADA at diagnosis of type 1 diabetes was confirmed. The effects of the <jats:italic>DQB1*06:02<\/jats:italic>\u2010positive haplotype seem to dominate when paired with a high\u2010risk haplotype.<\/jats:p>","DOI":"10.1111\/tan.15720","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T11:01:22Z","timestamp":1732100482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of Type 1 Diabetes Among Patients Carrying the Protective <scp>HLA<\/scp>\u2010<scp>DQB1<\/scp>*06:02 Allele"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-4978","authenticated-orcid":false,"given":"Antti\u2010Mathias","family":"Taka","sequence":"first","affiliation":[{"name":"Pediatric Research Center, New Children's Hospital Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program for Clinical and Molecular Metabolism, Faculty of Medicine University of Helsinki  Helsinki 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Metabolism, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"},{"name":"Liggins Institute University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-1468","authenticated-orcid":false,"given":"Johanna","family":"Lempainen","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory, Institute of Biomedicine University of Turku  Turku Finland"},{"name":"Department of Pediatrics University of Turku and Turku University Hospital  Turku Finland"},{"name":"Clinical Microbiology Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-270X","authenticated-orcid":false,"given":"Riitta","family":"Veijola","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Medicine University of Oulu  Oulu 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