{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:33:16Z","timestamp":1761294796226,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2024,11]]},"abstract":"ABSTRACT<\/jats:title>Haploidentical haematopoietic stem cell transplantation (haplo\u2010HSCT) is one of the most effective therapies for treating malignant haematological disorders. However, HLA disparities are significant barriers to the success of this process since they increase the risk of graft versus host disease (GvHD). HLA disparities quantification could help to anticipate the probability and degree of GvHD, but the best tool for such quantification remains a challenge. The aim of this study was to quantify the degree of HLA epitope incompatibilities using PIRCHE (Predicted Indirectly Recognisable HLA Epitopes) algorithm for immunogenicity prediction and their potential relationship with GvHD degree and clinical outcome. We studied 145 patients who underwent a haplo\u2010HSCT with post\u2010transplant cyclophosphamide (PTCy) from a related donor between 2013 and 2020 at our centre evaluating molecular HLA mismatches by PIRCHE\u2010algorithm. Patients with PIRCHE Score (PS) I\u2009+\u2009II\u2009>\u200938 in GvH direction, developed acute GvHD grade II\u2013IV earlier than their counterparts (HR: 1.71, 95% CI: 1.02\u20132.87, p<\/jats:italic>\u2009=\u20090.032). In addition, PS\u2010B\u2009>\u20091 in GvH direction was an independent risk factor for chronic GvHD, (HR: 2.51, 95% CI 1.17\u20135.36, p<\/jats:italic>\u2009=\u20090.017). A higher incidence of relapse was found for patients with PS\u2010II\u2009>\u200928 HvG (HR: 9.16, 95% CI: 2.47\u201333.92, p<\/jats:italic>\u2009<\u20090.001) which also favoured a worse GvHD\/relapse\u2010free survival in patients with PS\u2010II\u2009>\u200927 in HvG direction (HR: 1.88, 95% CI: 1.11\u20133.18, p<\/jats:italic>\u2009=\u20090.017). These findings indicate that the alloreactivity inferred by epitope HLA disparities is associated with post\u2010transplant outcomes. Thus, analysing PS could benefit the selection of the most suitable donors allowing patient stratification based on HLA mismatches in the context of haplo\u2010HSCT with PTCy.<\/jats:p>","DOI":"10.1111\/tan.15738","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:09:49Z","timestamp":1731499789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantifying HLA<\/scp> Mismatches at Epitope Level in Haplo\u2010HSCT<\/scp>: Impact in the Outcome in Strategies Using PTCy<\/scp>"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-0080","authenticated-orcid":false,"given":"Francisco Javier","family":"Gil\u2010Etayo","sequence":"first","affiliation":[{"name":"Department of Hematology University Hospital of Salamanca Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) Salamanca Spain"},{"name":"Centro 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