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We investigated the relationships between anti\u2010N protein antibody levels, severe acute respiratory syndrome (SARS)\u2010CoV\u20102\u2010associated TCR repertoire parameters, HLA type and epidemiological information from three cohorts of 524 SARS\u2010CoV\u20102\u2010infected subjects subgrouped in acute phase, seronegative and seropositive convalescents from the Emilia Romagna region. Epidemiological information and anti\u2010N antibody index were associated with TCR repertoire data. HLA type was inferred from TCR repertoire using the HLA3 tool and its association with clonal breadth (CB) and clonal depth (CD) was assessed. Age above 58\u2009years, male and COVID\u201019 hospitalisation were significantly and independently associated with seropositivity (<jats:italic>p<\/jats:italic>\u2009=\u20090.004; <jats:italic>p<\/jats:italic>\u2009=\u20090.004; <jats:italic>p<\/jats:italic>\u2009=\u20090.04), suggesting an association between high antibody titres and symptoms' severity. As for the TCR repertoire analysis, we found no difference in CB among the cohorts, while CD was higher in seronegative than acute (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). However, clustering analysis supported that seronegative patients are endowed with broader CB and deeper CD indicating a compensatory mechanism without effective seroconversion. The CD calculated on the TCRs associated with the single SARS\u2010CoV\u20102 ORFs in convalescents is higher when compared to the acute. Lastly, we identified and reported on novel HLAs significantly associated with increased risk of hospitalisation such as HLA\u2010C*07:02 carriers (OR\u2009=\u20093.9, CI\u2009=\u20091.1\u201313.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) and on HLAs that associate significantly with lower or higher TCR repertoire parameters in a population exposed for the first time to SARS\u2010CoV\u20102.<\/jats:p>","DOI":"10.1111\/tan.70011","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T12:01:38Z","timestamp":1736856098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Relationship Between Humoral and Cellular T Cell Responses Against <scp>SARS<\/scp>\u2010<scp>CoV<\/scp>\u20102 in Exposed Individuals From Emilia Romagna Region and <scp>COVID<\/scp>\u201019 Severity"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1253-8823","authenticated-orcid":false,"given":"Lucia","family":"Mazzotti","sequence":"first","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-8302","authenticated-orcid":false,"given":"Patricia","family":"Borges de Souza","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Azzali","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Angeli","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Nanni","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Sambri","sequence":"additional","affiliation":[{"name":"Microbiology Unit The Great Romagna Area Hub Laboratory  Pievesestina Italy"},{"name":"DIMEC Bologna University  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Semprini","sequence":"additional","affiliation":[{"name":"Microbiology Unit The Great Romagna Area Hub Laboratory  Pievesestina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bravaccini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Enna \u201cKore\u201d  Enna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cerchione","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gaimari","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Nicolini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ancarani","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Hematology and Sciences Oncology Institute of Haematology \u201cL. and A. 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