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Furthermore, in repeat transplantations, CD4+ memory T cells can lead to a more rapid immune response against repeated exposure to the same antigens. Several studies have shown that HLA and SLA proteins share overlapping B cell epitopes due to structural or electrostatic similarities, but the role of overlapping T cell epitopes has not been fully explored. This study aims to computationally analyse the potential risk of memory T cell activation in subsequent human\u2010after\u2010swine and swine\u2010after\u2010human transplantation by evaluating shared T cell epitopes between the two graft sources. We show that while HLA and SLA demonstrate striking structural similarities, their linear protein sequences are very distinct, which translates to disparate HLA\u2010 and SLA\u2010derived peptidomes and T cell epitopes. By applying the PIRCHE\u2010II Tmem analysis to a simulated panel of recipients receiving repeat transplantations from a human kidney and from a swine xenograft, we observed a median of 1 shared T cell epitope in the cross\u2010species context, compared to a median of 17 shared between two human\u2010derived kidneys. This suggests that a swine xenograft exposes a low risk of T cell memory against a later human donor, and that xenotransplantation may provide an opportunity to receive a graft for highly HLA\u2010sensitised recipients.<\/jats:p>","DOI":"10.1111\/tan.70291","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T20:24:42Z","timestamp":1750537482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Swine Xenografts Share Few Predicted Indirectly Recognisable <scp>SLA<\/scp>\u2010Derived Epitopes With <scp>HLA<\/scp>\u2010Derived Epitopes From Human Kidney Grafts"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-732X","authenticated-orcid":false,"given":"Benedict M.","family":"Matern","sequence":"first","affiliation":[{"name":"PIRCHE AG  Berlin Germany"},{"name":"University Medical Center Utrecht  Utrecht the 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