{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:37:45Z","timestamp":1792204665813,"version":"4.4.0"},"reference-count":142,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    molecules play a central role in the adaptive immune response. Their high polymorphism influences individual susceptibility to various autoimmune diseases and certain drug\u2010induced hypersensitivities. In France,\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    genotyping is classified as a medical genetics procedure and is strictly regulated. The Soci\u00e9t\u00e9 Francophone d'Histocompatibilit\u00e9 et d'Immunog\u00e9n\u00e9tique (\n                    <jats:styled-content style=\"fixed-case\">SFHI<\/jats:styled-content>\n                    ) has established national guidelines outlining clinically validated indications, required resolution levels and interpretation criteria based on robust data. These guidelines are particularly relevant for common clinical contexts, including autoimmune diseases and pharmacogenetic testing. Well\u2010established associations include\n                    <jats:italic>HLA\u2010DQB1*02<\/jats:italic>\n                    \/\n                    <jats:italic>DQA1*05<\/jats:italic>\n                    (DQ2) and\n                    <jats:italic>HLA\u2010DQB1*03:02<\/jats:italic>\n                    \/\n                    <jats:italic>DQA1*05<\/jats:italic>\n                    (DQ8) with celiac disease,\n                    <jats:italic>HLA\u2010B*27<\/jats:italic>\n                    with spondyloarthritis,\n                    <jats:italic>HLA\u2010DQB1*06:02<\/jats:italic>\n                    with type 1 narcolepsy,\n                    <jats:italic>HLA\u2010A*29<\/jats:italic>\n                    with Birdshot chorioretinopathy and several pharmacogenetic risk alleles such as\n                    <jats:italic>HLA\u2010B*57:01<\/jats:italic>\n                    (abacavir),\n                    <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                    and\n                    <jats:italic>HLA\u2010A*31:01<\/jats:italic>\n                    (carbamazepine) and\n                    <jats:italic>HLA\u2010B*58:01<\/jats:italic>\n                    (allopurinol). In immunotherapy, the efficacy of tebentafusp has been shown to depend on\n                    <jats:italic>HLA\u2010A*02:01<\/jats:italic>\n                    positivity. HLA alleles must be interpreted as relative risk factors, not absolute predictors. Critical analysis of HLA\u2010related scientific literature requires consideration of the genotyping technique, typing resolution, allele frequencies within the studied population and environmental factors. High\u2010resolution typing is essential in pharmacogenetics and recommended in selected autoimmune disorders. Interpretation should be conducted by qualified medical biologists, integrating clinical context, allelic diversity and recent technological advances, particularly next\u2010generation sequencing. HLA genotyping represents a valuable tool in diagnosis and risk assessment, with increasing importance in the era of personalised medicine.\n                  <\/jats:p>","DOI":"10.1111\/tan.70442","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:46:56Z","timestamp":1761396416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Guidelines From the French\u2010Speaking Society for Histocompatibility and Immunogenetics (\n                    <scp>SFHI<\/scp>\n                    ) for Harmonisation of\n                    <scp>HLA<\/scp>\n                    Genotyping in Autoimmune Diseases, Drug Hypersensitivity and Pharmacogenetics"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-4421","authenticated-orcid":false,"given":"Virginie","family":"Renac","sequence":"first","affiliation":[{"name":"Laboratoire 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