{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:49:24Z","timestamp":1775731764121,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Haploidentical haematopoietic stem cell transplantation (haplo\u2010HSCT) with post\u2010transplant cyclophosphamide (PTCy)\u2010based graft\u2010versus\u2010host disease (GVHD) prophylaxis is commonly used in patients without a fully matched donor. HLA evolutionary divergence (HED), a surrogate for the diversity of the immunopeptidome, can predict HLA\u2010matched HSCT outcomes. Because of the peculiarities of HED measurement in haplo\u2010HSCT, we designed a new HED\n                    <jats:sub>D\u2010&gt;R<\/jats:sub>\n                    metric to proxy the fraction of the recipient\u2010specific immunopeptidome not recognised as self by the haplo\u2010identical donor, and evaluated its predictive value on haplo\u2010HSCT outcomes with the aim of providing help in choosing the best donor. We retrospectively studied 104 patients who underwent PTCy haplo\u2010HSCT for haematological malignancy and calculated per\u2010locus and per\u2010class HED in the recipient (HED\n                    <jats:sub>R<\/jats:sub>\n                    ), the donor (HED\n                    <jats:sub>D<\/jats:sub>\n                    ), across mismatched haplotypes (HED\n                    <jats:sub>MM<\/jats:sub>\n                    ) as well as HED\n                    <jats:sub>D\u2010&gt;R<\/jats:sub>\n                    . Patients with low class 1 HED\n                    <jats:sub>R<\/jats:sub>\n                    had worse OS (hazard ratio (HR) 2.16, 95% confidence intervals (CI) 1.06\u20134.40,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.033), whereas no significant impact of HED\n                    <jats:sub>D<\/jats:sub>\n                    or HED\n                    <jats:sub>MM<\/jats:sub>\n                    at any HLA locus was observed. Moreover, in multivariate analysis of patients surviving at least 100\u2009days, low class 1 HED\n                    <jats:sub>D\u2010&gt;R<\/jats:sub>\n                    was associated with inferior OS (HR 2.67, 95% CI 1.13\u20136.28;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025). In addition to strengthening the impact of recipient class 1 HED on HSCT outcomes regardless of donor type, our results suggest that our novel, publicly available, HED\n                    <jats:sub>D\u2010&gt;R<\/jats:sub>\n                    metric could help select the most appropriate donor among haploidentical candidates.\n                  <\/jats:p>","DOI":"10.1111\/tan.70491","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:11:20Z","timestamp":1765375880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Harnessing\n                    <scp>HLA<\/scp>\n                    Divergence for Improved Donor Selection in Haploidentical Haematopoietic Stem Cell Transplantation"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-4131","authenticated-orcid":false,"given":"Debora","family":"Jorge Cordeiro","sequence":"first","affiliation":[{"name":"Laboratoire d'Immunologie et Histocompatibilit\u00e9, H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-7820","authenticated-orcid":false,"given":"Juliette","family":"Villemonteix","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie et Histocompatibilit\u00e9, H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-989X","authenticated-orcid":false,"given":"Alienor","family":"Xhaard","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie\u2010Greffe H\u00f4pital Saint\u2010Louis, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oph\u00e9lie","family":"Ferrary","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie et Histocompatibilit\u00e9, H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Dartois","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie et Histocompatibilit\u00e9, H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-4457","authenticated-orcid":false,"given":"Bruno A.","family":"Lima","sequence":"additional","affiliation":[{"name":"Oficina de Biostatistica  Ermesinde Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Toullec","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie et Histocompatibilit\u00e9, H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-4753","authenticated-orcid":false,"given":"Regis","family":"Peffault de Latour","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie\u2010Greffe H\u00f4pital Saint\u2010Louis, AP\u2010HP  Paris France"},{"name":"INSERM UMR1342, Institut de Recherche St\u2010Louis Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-3550","authenticated-orcid":false,"given":"Sophie","family":"Caillat\u2010Zucman","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie et Histocompatibilit\u00e9, H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"INSERM UMR1342, Institut de Recherche St\u2010Louis Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-7892","authenticated-orcid":false,"given":"Vincent","family":"Allain","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie et Histocompatibilit\u00e9, H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"INSERM UMR1342, Institut de Recherche 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