{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:29:20Z","timestamp":1790612960442,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Microvascular inflammation (MVI) in kidney allografts in the absence of detectable donor\u2010specific anti\u2010HLA antibodies (DSA) is increasingly recognised as a cause of premature graft failure following kidney transplantation. Potential mechanisms include NK cell alloreactivity mediated by recognition of mismatched HLA class I molecules (missing\u2010self) via killer\u2010immunoglobulin\u2010like receptors. Here, we report the case of an early kidney allograft rejection with severe MVI on biopsy in a patient that was fully HLA\u2010matched except for a\n                    <jats:italic>HLA\u2010DPB1*04<\/jats:italic>\n                    mismatch in the donor. There were no detectable DSA at any time. MVI was successfully reversed and clinically stabilised with a 9\u2010month course of daratumumab (anti\u2010CD38 mAb). This case suggests alternative mechanisms of alloreactivity, such as NK cell\u2010mediated effects, and highlights the existence of MVI in the absence of detectable B cell alloreactivity. Moreover, this case exemplifies the potential of anti\u2010CD38 treatment in these patients.\n                  <\/jats:p>","DOI":"10.1111\/tan.70560","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T05:42:19Z","timestamp":1768023739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Rejection With\n                    <scp>DSA<\/scp>\n                    \u2010Negative Severe Microvascular Inflammation in a Kidney Transplant Recipient With an Isolated\n                    <i>DPB1*04<\/i>\n                    \u2010Mismatch Successfully Stabilised With Daratumumab"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9259-5298","authenticated-orcid":false,"given":"Laura","family":"Kn\u00f6dl","sequence":"first","affiliation":[{"name":"Department of Nephrology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"B\u00fcttner\u2010Herold","sequence":"additional","affiliation":[{"name":"Department of Nephropathology Institute of Pathology, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010Nuremberg (FAU) and University Hospital  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Luber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5\u2010Hematology and Oncology University Hospital Erlangen, Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Spriewald","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5\u2010Hematology and Oncology University Hospital Erlangen, Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Oellerich","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Beck","sequence":"additional","affiliation":[{"name":"Chronix Biomedical GmbH  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Banas","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zecher","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1802677"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020030306"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.11.029"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005228"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020040433"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2400763"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2002.01053.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003247"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15898"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004624"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.210328"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00428-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.10.016"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.07.023"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050429"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00862-w"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0448-4"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2019.01.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.08.006"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.70560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.70560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.70560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:47:49Z","timestamp":1772970469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.70560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/tan.70560"],"URL":"https:\/\/doi.org\/10.1111\/tan.70560","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70560"}}