{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:03:03Z","timestamp":1779771783976,"version":"3.53.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341206"],"award-info":[{"award-number":["82341206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270234"],"award-info":[{"award-number":["82270234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270235"],"award-info":[{"award-number":["82270235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403700"],"award-info":[{"award-number":["2023YFC3403700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202111004"],"award-info":[{"award-number":["SZSM202111004"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Antibodies targeting foreign HLA molecules can be detrimental in transplantation. Nonetheless, existing desensitisation methods for anti\u2010HLA antibodies frequently prove insufficient. We conducted a single\u2010arm pilot study to evaluate CD19\/B cell maturation antigen (BCMA) chimeric antigen receptor T (CAR\u2010T) cell therapy for desensitising anti\u2010HLA antibodies prior to transplantation. Seven patients diagnosed with acute leukaemia participated in the study, comprising four individuals with acute myeloid leukaemia (AML) and three with acute B lymphoblastic leukaemia (B\u2010ALL). Among them, one patient was treated with BCMA CAR\u2010T cells, while six received CD19 CAR\u2010T cells. No instances of neurotoxicity or severe cytokine release syndrome (grade \u2265\u20093) were noted. CAR\u2010T cell expansion was observed in six patients (86%), with the exception of patient 3. Among the seven patients with pre\u2010infusion anti\u2010HLA\u2010I antibodies, five (71%) showed a decrease in mean fluorescence intensity (MFI), including three (43%) who experienced a reduction greater than 75%. Among the six patients confirmed to exhibit CAR\u2010T cell expansion in\u00a0vivo, three presented with donor\u2010specific anti\u2010HLA antibodies (DSAs) prior to CAR\u2010T cell infusion. The median MFI level of DSA declined from 15797.8 (7750.3\u201321106.0) to 3831.1 (523.3\u201313197.0) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in the three patients studied. Two patients with decreased DSA levels after CD19 CAR\u2010T cell infusion underwent combined desensitisation before haematopoietic stem cell transplantation. This pilot study illustrates the potential safety and efficacy of CD19 and BCMA CAR\u2010T cells in desensitising anti\u2010HLA antibodies in patients with AML or B\u2010ALL. However, only one patient received BCMA CAR\u2010T cells in our cohort, so further research with an expanded sample size is essential for comprehensively evaluating the safety and efficacy of CD19\/BCMA CAR\u2010T cell therapy for anti\u2010HLA antibody sensitisation.\n                  <\/jats:p>","DOI":"10.1111\/tan.70701","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:30:22Z","timestamp":1778902222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CD19<\/scp>\n                    \/\n                    <scp>BCMA<\/scp>\n                    \u2010Targeted Chimeric Antigen Receptor\u2010T Cell Therapy for Anti\u2010\n                    <scp>HLA<\/scp>\n                    Antibody Sensitisation in Patients With Acute Leukaemia: A Pilot Clinical Study"],"prefix":"10.1111","volume":"107","author":[{"given":"Haiqiong","family":"Zheng","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9522-4938","authenticated-orcid":false,"given":"Houli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Feng","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Wei","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Han","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simao","family":"Huang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Cui","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Fu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; 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