{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:03:10Z","timestamp":1779771790999,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["70115382"],"award-info":[{"award-number":["70115382"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tebentafusp, a T\u2010cell receptor\u2010bispecific molecule targeting glycoprotein 100\u2010derived peptide presented by HLA class I molecule and CD3, is standard of care for patients with unresectable or metastatic uveal melanoma who are positive for\n                    <jats:italic>HLA\u2010A*02:01<\/jats:italic>\n                    . Mechanisms of resistance to tebentafusp are unknown. We report a patient with metastatic uveal melanoma who acquired resistance to tebentafusp after 30\u2009months of treatment. Genomic loss of the HLA\u2010haplotype carrying the\n                    <jats:italic>HLA\u2010A*02:01<\/jats:italic>\n                    restriction element was detected in a progressive metastasis, resulting in loss of presentation of tebentafusp's target antigen. Understanding mechanisms of resistance against synthetic cancer immunotherapies will be key to monitoring disease control and development of early intervention strategies towards cure.\n                  <\/jats:p>","DOI":"10.1111\/tan.70764","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:56:37Z","timestamp":1779353797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Escape From Synthetic T Cell Activator Tebentafusp by Genomic\n                    <scp>HLA<\/scp>\n                    Loss: A Case Report"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0090-4080","authenticated-orcid":false,"given":"Halime","family":"Kalkavan","sequence":"first","affiliation":[{"name":"Department of Medical Oncology West German Cancer Center, University Hospital Essen  Essen Germany"},{"name":"Medical Faculty, University Duisburg\u2010Essen  Essen 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