{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:44:14Z","timestamp":1792395854133,"version":"4.4.0"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HLA"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    HLA loci have been implicated in several diseases, including HIV\u20101, from different world populations. It is necessary to characterise HLA allele variation at the population level prior to investigating associations linked to human diseases. In global databases, limited high\u2010resolution HLA allele types generated by next\u2010generation sequencing (NGS) have been described for populations from African countries. We sought to expand our NGS\u2010based HLA genotyping database to include a total of 1023 participants from multiple clinical studies using a contiguous full\u2010length gene sequencing approach. Collectively we describe HLA genotypes of individuals from Kenya (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009375), Uganda (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009338), Nigeria (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009139), Tanzania (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200989) and Mozambique (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200982). Overall, we identified 362 unique HLA alleles across 11 loci with the most frequent at each locus being\n                    <jats:italic>A*02:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>B*53:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>C*04:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>C*06:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DPA1*01:03:01<\/jats:italic>\n                    ,\n                    <jats:italic>DPB1*01:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>DQA1*01:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DQB1*06:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DRB1*15:03:01<\/jats:italic>\n                    ,\n                    <jats:italic>DRB3*02:02:01<\/jats:italic>\n                    ,\n                    <jats:italic>DRB4*01:03:01<\/jats:italic>\n                    and\n                    <jats:italic>DRB5*01:01:01<\/jats:italic>\n                    . A total of 24 novel alleles (HLA\u2010A (2), B (1), C (1), DPA1 (4), DPB1 (6), DQA1 (3), DRB1 (6) and DRB3 (1)) were identified, including 3 (\n                    <jats:italic>C*07:1218<\/jats:italic>\n                    ,\n                    <jats:italic>DQA1*01:190<\/jats:italic>\n                    and\n                    <jats:italic>DPB1*1820:01<\/jats:italic>\n                    ) with non\u2010synonymous changes affecting the peptide binding groove of HLA molecules. This expansion of NGS based HLA data at the African population level will improve our understanding of human genetic variation and provide insights for disease association, vaccine development and targeted personalised therapies.\n                  <\/jats:p>","DOI":"10.1111\/tan.70814","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:40:07Z","timestamp":1782528007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Full\u2010Length Next\u2010Generation Sequencing of 11\n                    <scp>HLA<\/scp>\n                    Loci of More Than 1000 Individuals From Clinical Cohorts in East and West Africa"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7883-9336","authenticated-orcid":false,"given":"Yvonne V.","family":"Rosario","sequence":"first","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Inc  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Geretz","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Inc  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi Rani","family":"Iyer","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Inc  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip K.","family":"Ehrenberg","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u00fda","family":"Tyson","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Inc  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kibuuka","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Program  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Wabwire\u2010Mangen","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Program  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Maganga","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research Africa  Nairobi Kenya"},{"name":"HJF Medical Research International  Mbeya Tanzania"},{"name":"National Institute for Medical Research\u2010Mbeya Medical Research Center  Mbeya Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulwasiu","family":"Tiamiyu","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"HJF Medical Research International Ltd\/Gte  Abuja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah","family":"Maswai","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research Africa  Nairobi Kenya"},{"name":"HJF Medical Research International  Kericho Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josphat","family":"Kosgei","sequence":"additional","affiliation":[{"name":"HJF Medical Research International  Kericho Kenya"},{"name":"Kenya Medical Research Institute\/Walter Reed Army Institute of Research\u2013Africa  Kericho Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Sawe","sequence":"additional","affiliation":[{"name":"HJF Medical Research International  Kericho Kenya"},{"name":"Kenya Medical Research Institute\/Walter Reed Army Institute of Research\u2013Africa  Kericho Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R.","family":"Matyas","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlin L.","family":"Robb","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. 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